Cyclobuxine D

Modify Date: 2025-08-20 00:34:25

Cyclobuxine D Structure
Cyclobuxine D structure
 Common Name Cyclobuxine D
CAS Number 2241-90-9 Molecular Weight 386.61400
Density 1.08g/cm3 Boiling Point 494.2ºC at 760mmHg
Molecular Formula C25H42N2O Melting Point 236-238ºC
MSDS N/A Flash Point 53.5ºC

 Use of Cyclobuxine D


Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba++−induced contraction of the longitudinal muscle isolated from the rabbit jejunum[1][2].

 Names

Name cyclobuxine-d
Synonym More Synonyms

 Cyclobuxine D Biological Activity

Description Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba++−induced contraction of the longitudinal muscle isolated from the rabbit jejunum[1][2].
Related Catalog
References

[1]. . A. Eshonov, et al. Alkaloids of Buxus sempervirens, Crystal and Molecular Structure of Cyclobuxine-D and Imperialine. Chemistry of Natural Compounds. 12 January 2014. 49:11791182.

[2]. Kwon, Jun-Tack, et al. Effects of Cyclobuxine D on Drug-Induced Contractions of the Isolated Rat Uterine Muscle and Potassium-Activated Calcium Channels in an Intestinal Smooth Muscle. The Korean Journal of Pharmacology. 1988. 24 (1): 103-109.

 Chemical & Physical Properties

Density 1.08g/cm3
Boiling Point 494.2ºC at 760mmHg
Melting Point 236-238ºC
Molecular Formula C25H42N2O
Molecular Weight 386.61400
Flash Point 53.5ºC
Exact Mass 386.33000
PSA 44.29000
LogP 4.90400
Vapour Pressure 7.7E-12mmHg at 25°C
Index of Refraction 1.561

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GZ0590020
CHEMICAL NAME :
9,19-Cyclo-5-alpha,9-beta-pregnan-16-alpha-ol, 14-methyl-3-beta,20-alpha-bis(methylamino)-4- methylene-
CAS REGISTRY NUMBER :
2241-90-9
LAST UPDATED :
198909
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C25-H42-N2-O
MOLECULAR WEIGHT :
386.69

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),217,1982

 Synonyms

cyclobuxine
cyclobuxine D
(3beta,5alpha,16alpha,20S)-14-Methyl-3,20-bis(methylamino)-4-methylene-9,19-cyclopregnan-16-ol
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