AUTAC2
Modify Date: 2025-08-24 21:03:47
AUTAC2 structure
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Common Name | AUTAC2 | ||
|---|---|---|---|---|
| CAS Number | 2241669-08-7 | Molecular Weight | 1229.42 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C61H81FN10O14S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AUTAC2AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12[1]. |
| Name | AUTAC2 |
|---|
| Description | AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12[1]. |
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| Related Catalog | |
| In Vitro | AUTAC1 (1-100 μM, 24 h) silences endogenous FKBP12 in hela cells[1]. Western Blot Analysis[1] Cell Line: HeLa cells. Concentration: 0-100 μM. Incubation Time: 24 h. Result: Silenced endogenous FKBP12. |
| References |
| Molecular Formula | C61H81FN10O14S |
|---|---|
| Molecular Weight | 1229.42 |
| InChIKey | PZCJWAJPLITJCB-YQZOKAAQSA-N |
| SMILES | CCC(C)(C)C(=O)C(=O)N1CCCCC1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(NC(=O)CCC(=O)NCCCOCCOCCOCCCNC(=O)C(CSc2nc3c(=O)[nH]c(N)nc3n2Cc2ccc(F)cc2)NC(C)=O)c1 |