E7766 disodium

Modify Date: 2024-01-11 01:07:58

E7766 disodium structure	Common Name	E7766 disodium
	CAS Number	2242636-28-6	Molecular Weight	792.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₆F₂N₁₀Na₂O₈P₂S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of E7766 disodium

E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities[1].

Name	E7766 disodium

Description	E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> STING
In Vitro	E7766 disodium inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC50 values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively[1].
In Vivo	In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 disodium in the subcutaneous tumor. E7766 disodium is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model[1].
References	[1]. Dae-Shik Kim, et al. E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity. ChemMedChem. 2021 Jun 7;16(11):1740-1743.

Molecular Formula	C₂₄H₂₆F₂N₁₀Na₂O₈P₂S₂
Molecular Weight	792.58

DC Chemicals Limited
China
Product Name: E7766 disodium
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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