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5550-12-9

5550-12-9 structure
5550-12-9 structure
  • Name: GMP disodium salt
  • Chemical Name: Guanosine 5'-monophosphate disodium salt
  • CAS Number: 5550-12-9
  • Molecular Formula: C10H12N5Na2O8P
  • Molecular Weight: 407.184
  • Catalog: Biochemical Nucleoside drugs Nucleotides and their analogues
  • Create Date: 2018-04-06 08:00:00
  • Modify Date: 2024-01-02 11:27:57
  • 5'-Guanylic acid disodium salt (5'-GMP disodium salt) is composed of guanine, ribose, and phosphate moieties and it is a nucleotide monomer in messenger RNA. Guanosine derivatives are involved in intracellular signal transduction and have been identified in repetitive genomic sequences in telomeres, in ribosomal DNA, immunoglobulin heavy‐chain switch regions, and in the control regions of proto-oncogenes[1].
Name Guanosine 5'-monophosphate disodium salt
Synonyms Sodium Guanylate
MFCD00070575
Disodium 2-amino-9-(5-O-phosphonato-β-D-ribofuranosyl)-9H-purin-6-ol
2'(3')-GMP
GMP
GMP disodium salt
5'-GMP disodium salt
Guanosine 5'-monophosphate disodium salt
Na2(5'-GMP)
5'-guanosine monophosphate disodium salt
sodiumgmp
EINECS 226-914-1
Disodium 5'-guanylate
5'-GMP-NA2
Disodium guanosine 5'-monophosphate
5'-Guanylic acid, sodium salt (1:2)
9H-purin-6-ol, 2-amino-9-(5-O-phosphono-β-D-ribofuranosyl)-, sodium salt (1:2)
5'-GMP 2NA
disodiumgmp
5'-Guanylic acid disodium salt
Disodium 5'-O-phosphonatoguanosine
GMP-5
GMP-2Na
FEMA 3668
Description 5'-Guanylic acid disodium salt (5'-GMP disodium salt) is composed of guanine, ribose, and phosphate moieties and it is a nucleotide monomer in messenger RNA. Guanosine derivatives are involved in intracellular signal transduction and have been identified in repetitive genomic sequences in telomeres, in ribosomal DNA, immunoglobulin heavy‐chain switch regions, and in the control regions of proto-oncogenes[1].
Related Catalog
Target

Human Endogenous Metabolite
References

[1]. Lan T, et al. Type II cGMP-dependent protein kinase phosphorylates EGFR at threonine 669 and thereby inhibits its activation. Biochem Biophys Res Commun. 2019 Aug 6.
Boiling Point 890.2ºC at 760 mmHg
Melting Point 300°C
Molecular Formula C10H12N5Na2O8P
Molecular Weight 407.184
Flash Point 492.2ºC
Exact Mass 407.021881
PSA 221.51000
Storage condition 2-8°C
Water Solubility >50 g/L

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MF9290000
CHEMICAL NAME :
5'-Guanylic acid, disodium salt
CAS REGISTRY NUMBER :
5550-12-9
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C10-H12-N5-O8-P.2Na
MOLECULAR WEIGHT :
407.22
WISWESSER LINE NOTATION :
T56 BN DN FN HNVJ GZ D- BT5OTJ CQ DQ E1OPO&O&O &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>17300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3880 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2720 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5010 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5050 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3580 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Fibroblast
DOSE/DURATION :
1 gm/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1092 No. of Facilities: 177 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 1410 (estimated) No. of Female Employees: 33 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS MF9290000
HS Code 29349990
Precursor  0

DownStream  2

HS Code 29349990

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