DW14800

Modify Date: 2025-08-20 16:51:43

DW14800 Structure
DW14800 structure
Common Name DW14800
CAS Number 2243709-60-4 Molecular Weight 512.64
Density N/A Boiling Point N/A
Molecular Formula C31H36N4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DW14800


DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity[1].

 Names

Name DW14800

 DW14800 Biological Activity

Description DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity[1].
Related Catalog
Target

PRMT5[1]

References

[1]. Zheng BN, et al. Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α. Theranostics. 2019 Apr 13;9(9):2606-2617.

 Chemical & Physical Properties

Molecular Formula C31H36N4O3
Molecular Weight 512.64
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