GPR84 antagonist 2

Modify Date: 2025-08-27 11:18:14

GPR84 antagonist 2 Structure
GPR84 antagonist 2 structure
Common Name GPR84 antagonist 2
CAS Number 2244269-74-5 Molecular Weight 605.42
Density N/A Boiling Point N/A
Molecular Formula C28H16Cl2NaO4PS2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GPR84 antagonist 2


GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). GPR84 antagonist 2 shows improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. GPR84 antagonist 2 has the potential for the research of ulcerative colitis[1].

 Names

Name GPR84 antagonist 2

 GPR84 antagonist 2 Biological Activity

Description GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). GPR84 antagonist 2 shows improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. GPR84 antagonist 2 has the potential for the research of ulcerative colitis[1].
Related Catalog
References

[1]. Chen LH, et al. Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis. J Med Chem. 2022;65(5):3991-4006.

 Chemical & Physical Properties

Molecular Formula C28H16Cl2NaO4PS2
Molecular Weight 605.42
InChIKey JFIDCMUEKCPJLL-UHFFFAOYSA-M
SMILES O=P([O-])(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21.[Na+]
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