BI-4924
Modify Date: 2025-08-24 21:03:23
BI-4924 structure
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Common Name | BI-4924 | ||
|---|---|---|---|---|
| CAS Number | 2244452-09-1 | Molecular Weight | 499.36 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H20Cl2N2O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BI-4924BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h[1]. |
| Name | BI-4924 |
|---|
| Description | BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h[1]. |
|---|---|
| Related Catalog | |
| Target |
PHGDH[1] |
| In Vitro | BI-4924 is a highly potent co-factor nicotinamide adenine dinucleotide (NADH/NAD+)-competitive PHGDH inhibitor. BI-4924 shows high selectivity against the majority of other dehydrogenase targets[1]. |
| References |
| Molecular Formula | C21H20Cl2N2O6S |
|---|---|
| Molecular Weight | 499.36 |
| InChIKey | CJEJFFCPVBZSIE-OAHLLOKOSA-N |
| SMILES | Cc1cc2c(cc(C(=O)NC(CO)c3ccc(S(=O)(=O)CC(=O)O)cc3)n2C)c(Cl)c1Cl |