Isecarosmab
Modify Date: 2024-04-09 18:32:08
Isecarosmab structure
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Common Name | Isecarosmab | ||
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| CAS Number | 2254082-79-4 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IsecarosmabIsecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life[1][2][3]. |
| Name | Isecarosmab |
|---|
| Description | Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life[1][2][3]. |
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| Related Catalog | |
| In Vitro | Isecarosmab 结合 ADAMTS-5，但不结合 ADAMTS-1、ADAMTS-4 和 ADAMTS-15[1]。 Isecarosmab (1-100 nM，5 天) 在受到促炎刺激的牛和 OA 人软骨外植体中降低 huARGS、exAGNxI 和 GAG 水平[1]。 Isecarosmab (24-72 h) 阻断 ADAMTS-5 介导的 DCS TLR2 激活[2]。 |
| In Vivo | Isecarosmab (0.1-10 mg/kg，皮下注射，每三天一次) 减轻内侧半月板 (DMM) 切除小鼠的内侧软骨退化[1]。 |
| References |
| No Any Chemical & Physical Properties |