Ep300/CREBBP-IN-4
Modify Date: 2025-08-25 15:59:43
Ep300/CREBBP-IN-4 structure
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Common Name | Ep300/CREBBP-IN-4 | ||
|---|---|---|---|---|
| CAS Number | 2259641-42-2 | Molecular Weight | 473.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H22F3N5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Ep300/CREBBP-IN-4Ep300/CREBBP-IN-4 (Example 56) is a potent Ep300 and CREBBP inhibitor with IC50s of 0.024 and 0.064 μM, respectively. Ep300/CREBBP-IN-4 can be used for the research of cancer[1]. |
| Name | Ep300/CREBBP-IN-4 |
|---|
| Description | Ep300/CREBBP-IN-4 (Example 56) is a potent Ep300 and CREBBP inhibitor with IC50s of 0.024 and 0.064 μM, respectively. Ep300/CREBBP-IN-4 can be used for the research of cancer[1]. |
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| Related Catalog | |
| Target |
EP300:0.024 μM (IC50) CREBBP:0.064 μM (IC50) |
| In Vitro | Ep300/CREBBP-IN-4 (Example 56) 抑制细胞内 H3K27Ac 活性，其 IC50 为 0.020 μM[1]。 Ep300/CREBBP-IN-4 (38 nM-10 mM; 3 days) 抑制 LK2 和 TE-8 细胞生长，GI50 分别为 98.803 μM 和 88.333 μM [1]。 Cell Viability Assay[1] Cell Line: LK2 and TE-8 cells Concentration: 38 nM-10 mM Incubation Time: 3 days Result: Inhibited LK2 and TE-8 cell growth with GI50s of 98.803 and 88.333 μM, respectively. |
| References |
[1]. NAITO Hiroyuki, et al. EP300 / CREBBP inhibitor. Patent JPWO2018235966A1. |
| Molecular Formula | C23H22F3N5O3 |
|---|---|
| Molecular Weight | 473.45 |
| InChIKey | TURGXTFEXLEVEN-RDTXWAMCSA-N |
| SMILES | COc1ccc(C2(C(=O)N3CC(F)CC3C(=O)Nc3ccc4[nH]ncc4n3)CC(F)(F)C2)cc1 |