Ep300/CREBBP-IN-3

Modify Date: 2024-01-02 19:38:37

Ep300/CREBBP-IN-3 Structure
Ep300/CREBBP-IN-3 structure
Common Name Ep300/CREBBP-IN-3
CAS Number 2259641-47-7 Molecular Weight 531.50
Density N/A Boiling Point N/A
Molecular Formula C26H25F4N5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ep300/CREBBP-IN-3


Ep300/CREBBP-IN-3 (Example 61) is a potent Ep300 and CREBBP inhibitor with IC50s of 0.056 and 0.095 μM, respectively. Ep300/CREBBP-IN-3 can be used for the research of cancer[1].

 Names

Name Ep300/CREBBP-IN-3

 Ep300/CREBBP-IN-3 Biological Activity

Description Ep300/CREBBP-IN-3 (Example 61) is a potent Ep300 and CREBBP inhibitor with IC50s of 0.056 and 0.095 μM, respectively. Ep300/CREBBP-IN-3 can be used for the research of cancer[1].
Related Catalog
Target

EP300:0.056 μM (IC50)

CREBBP:0.095 μM (IC50)

In Vitro Ep300/CREBBP-IN-3 (Example 61) 抑制细胞内 H3K27Ac 活性,其 IC50 为 0.021 μM[1]。 Ep300/CREBBP-IN-3 (38 nM-10 mM; 3 days) 抑制 LK2 和 TE-8 细胞生长,GI50 分别为 148.858 μM 和 215.717 μM [1]。 Cell Viability Assay[1] Cell Line: LK2 and TE-8 cells Concentration: 38 nM-10 mM Incubation Time: 3 days Result: Inhibited LK2 and TE-8 cell growth with GI50s of 148.858 and 215.717 μM, respectively.
References

[1]. NAITO Hiroyuki, et al. EP300 / CREBBP inhibitor. Patent JPWO2018235966A1.

 Chemical & Physical Properties

Molecular Formula C26H25F4N5O3
Molecular Weight 531.50