IM-250

Modify Date: 2024-01-04 15:31:13

IM-250 Structure
IM-250 structure
 Common Name IM-250
CAS Number 2305750-23-4 Molecular Weight 435.51
Density N/A Boiling Point N/A
Molecular Formula C20H19F2N3O2S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of IM-250


IM-250 is a potent HSV-1 helicase primase inhibitor, inhibits HSV-1 replication with IC50 of 20 nM (clinical isolate of HSV-1).IM-250 dispalys similar IC50 values (20-30 nM) against ACV-resistant HSV-1 clinical isolates 2 and 3 and ACV-resistant HSV-2 clinical isolates 7 and 8.IM-250 exhibits a broad therapeutic window against HSV-1 in vitro with pronounced higher SI values as obtained for acyclovir (ACV).IM-250 shows in vivo efficacy and attenuates viral burden in HSV-1 infection mouse model.

 Names

Name IM-250

 IM-250 Biological Activity

Description IM-250 is a potent HSV-1 helicase primase inhibitor, inhibits HSV-1 replication with IC50 of 20 nM (clinical isolate of HSV-1).IM-250 dispalys similar IC50 values (20-30 nM) against ACV-resistant HSV-1 clinical isolates 2 and 3 and ACV-resistant HSV-2 clinical isolates 7 and 8.IM-250 exhibits a broad therapeutic window against HSV-1 in vitro with pronounced higher SI values as obtained for acyclovir (ACV).IM-250 shows in vivo efficacy and attenuates viral burden in HSV-1 infection mouse model.
References 1. Uhlig N, et al. Antiviral Res. 2021 Nov;195:105190.

 Chemical & Physical Properties

Molecular Formula C20H19F2N3O2S2
Molecular Weight 435.51
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Chemsrc provides IM-250(CAS#:2305750-23-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of IM-250 are included as well.>> amp version: IM-250

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