IM-250
Modify Date: 2024-01-04 15:31:13
IM-250 structure
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Common Name | IM-250 | ||
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| CAS Number | 2305750-23-4 | Molecular Weight | 435.51 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H19F2N3O2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IM-250IM-250 is a potent HSV-1 helicase primase inhibitor, inhibits HSV-1 replication with IC50 of 20 nM (clinical isolate of HSV-1).IM-250 dispalys similar IC50 values (20-30 nM) against ACV-resistant HSV-1 clinical isolates 2 and 3 and ACV-resistant HSV-2 clinical isolates 7 and 8.IM-250 exhibits a broad therapeutic window against HSV-1 in vitro with pronounced higher SI values as obtained for acyclovir (ACV).IM-250 shows in vivo efficacy and attenuates viral burden in HSV-1 infection mouse model. |
| Name | IM-250 |
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| Description | IM-250 is a potent HSV-1 helicase primase inhibitor, inhibits HSV-1 replication with IC50 of 20 nM (clinical isolate of HSV-1).IM-250 dispalys similar IC50 values (20-30 nM) against ACV-resistant HSV-1 clinical isolates 2 and 3 and ACV-resistant HSV-2 clinical isolates 7 and 8.IM-250 exhibits a broad therapeutic window against HSV-1 in vitro with pronounced higher SI values as obtained for acyclovir (ACV).IM-250 shows in vivo efficacy and attenuates viral burden in HSV-1 infection mouse model. |
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| References | 1. Uhlig N, et al. Antiviral Res. 2021 Nov;195:105190. |
| Molecular Formula | C20H19F2N3O2S2 |
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| Molecular Weight | 435.51 |