MeOIstPyrd

Modify Date: 2024-01-04 15:35:17

MeOIstPyrd structure	Common Name	MeOIstPyrd
	CAS Number	2308548-54-9	Molecular Weight	304.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₆N₄O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MeOIstPyrd

MeOIstPyrd is an anti-skin cancer agent. MeOIstPyrd inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. MeOIstPyrd induces DNA damage. MeOIstPyrd activates p53, and increases the half-life of p53 and stabilizes p53 by phosphorylating it at ser15. MeOIstPyrd binds to MDM2 in the p53 sub-pocket and blocks p53-MDM2 interaction[1].

Name	MeOIstPyrd

Description	MeOIstPyrd is an anti-skin cancer agent. MeOIstPyrd inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. MeOIstPyrd induces DNA damage. MeOIstPyrd activates p53, and increases the half-life of p53 and stabilizes p53 by phosphorylating it at ser15. MeOIstPyrd binds to MDM2 in the p53 sub-pocket and blocks p53-MDM2 interaction[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53
References	[1]. Nerina Shahi, et al. 5-Methoxyisatin N(4)-Pyrrolidinyl Thiosemicarbazone (MeOIstPyrd) Restores Mutant p53 and Inhibits the Growth of Skin Cancer Cells, In Vitro. https://pubs.acs.org/doi/10.1021/acsomega.3c03824. ACS Omega 2023, 8, 35, 31998鈥?2016.

Molecular Formula	C₁₄H₁₆N₄O₂S
Molecular Weight	304.37

MeOIstPyrd

Use of MeOIstPyrd

Names

MeOIstPyrd Biological Activity

Chemical & Physical Properties