LDN-192960 hydrochloride
Modify Date: 2024-01-10 02:09:08
LDN-192960 hydrochloride structure
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Common Name | LDN-192960 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 2309172-48-1 | Molecular Weight | 401.35 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H22Cl2N2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LDN-192960 hydrochlorideLDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1]. |
| Name | LDN-192960 hydrochloride |
|---|
| Description | LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1]. |
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| Related Catalog | |
| Target |
IC50: 10 nM (Haspin); 48 nM (DYRK2)[1] |
| In Vitro | LDN-192960 hydrochloride (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC50<1 μM), including CLK1 (IC50=0.21 μM), DYRK1A (IC50= 0.10 μM), DYRK2 (IC50=2 nM), DYRK3 (IC50=19 nM) and PIM1 (IC50=0.72 μM)[1]. |
| References |
| Molecular Formula | C18H22Cl2N2O2S |
|---|---|
| Molecular Weight | 401.35 |