fumagillin structure
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Common Name | fumagillin | ||
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CAS Number | 23110-15-8 | Molecular Weight | 458.54400 | |
Density | 1.19g/cm3 | Boiling Point | 608.8ºC at 760mmHg | |
Molecular Formula | C26H34O7 | Melting Point | >190ºC-192ºC | |
MSDS | Chinese USA | Flash Point | 198.8ºC | |
Symbol |
GHS02, GHS07 |
Signal Word | Danger |
Use of fumagillinFumagillin(NSC9168) is a complex biomolecule and used as an antimicrobial agent.Target: AntiparasiticFumagillin is an active amebicide and anti-infective isolated from the fungus Aspergillus fumigatus. Fumagillin does exhibit some side effects that have deterred its acceptance as a viable treatment, but the current body of research on the synthesis of novel analogs of this molecule shows an exciting and promising revival of this drug as both an anti-infective and antiangiogenic agent [1]. |
Name | fumagillin |
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Synonym | More Synonyms |
Description | Fumagillin(NSC9168) is a complex biomolecule and used as an antimicrobial agent.Target: AntiparasiticFumagillin is an active amebicide and anti-infective isolated from the fungus Aspergillus fumigatus. Fumagillin does exhibit some side effects that have deterred its acceptance as a viable treatment, but the current body of research on the synthesis of novel analogs of this molecule shows an exciting and promising revival of this drug as both an anti-infective and antiangiogenic agent [1]. |
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Related Catalog | |
References |
Density | 1.19g/cm3 |
---|---|
Boiling Point | 608.8ºC at 760mmHg |
Melting Point | >190ºC-192ºC |
Molecular Formula | C26H34O7 |
Molecular Weight | 458.54400 |
Flash Point | 198.8ºC |
Exact Mass | 458.23000 |
PSA | 97.89000 |
LogP | 3.91540 |
Vapour Pressure | 2.7E-16mmHg at 25°C |
Index of Refraction | 1.562 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS02, GHS07 |
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Signal Word | Danger |
Hazard Statements | H225-H302-H312-H319-H332 |
Precautionary Statements | P210-P280-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xn: Harmful; |
Risk Phrases | R22 |
Safety Phrases | 36 |
RIDADR | UN 1648 3 / PGII |
WGK Germany | 3 |
RTECS | HE1750000 |
HS Code | 29419090 |
Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide.
ACS Nano 8(7) , 7305-17, (2014) Antiangiogenesis has been extensively explored for the treatment of a variety of cancers and certain inflammatory processes. Fumagillin, a mycotoxin produced by Aspergillus fumigatus that binds methio... |
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Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats.
PLoS ONE 7(4) , e35388, (2012) Pulmonary Hypertension (PH) is a pathophysiologic condition characterized by hypoxemia and right ventricular strain. Proliferation of fibroblasts, smooth muscle cells, and endothelial cells is central... |
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The Aspergillus fumigatus toxin fumagillin suppresses the immune response of Galleria mellonella larvae by inhibiting the action of haemocytes.
Microbiology 157(Pt 5) , 1481-8, (2011) Larvae of Galleria mellonella are widely used to evaluate microbial virulence and to assess the in vivo efficacy of antimicrobial agents. The aim of this work was to examine the ability of an Aspergil... |
FUGILLIN |
FUMADIL B |
amebacillin |
(2E,4E,6E,8E)-10-({(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl}oxy)-10-oxo-2,4,6,8-decatetraenoic acid |
fumagillin |
(2E,4E,6E,8E)-10-({(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl}oxy)-10-oxodeca-2,4,6,8-tetraenoic acid |
EINECS 245-433-8 |
MFCD03990453 |
fumidil |
h-3 |
FUMIDIL B |
AMEBACILIN |
2,4,6,8-Decatetraenedioic acid, mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] ester, (2E,4E,6E,8E)- |
mono[5-methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]octan-6-yl]ester |
fugilin |