Virginiamycin S1

Modify Date: 2024-01-08 13:51:14

Virginiamycin S1 Structure
Virginiamycin S1 structure
Common Name Virginiamycin S1
CAS Number 23152-29-6 Molecular Weight 823.89000
Density N/A Boiling Point N/A
Molecular Formula C43H49N7O10 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of Virginiamycin S1


Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections[1][2].

 Names

Name virginiamycin S1
Synonym More Synonyms

 Virginiamycin S1 Biological Activity

Description Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections[1][2].
Related Catalog
References

[1]. Ningsih F, et al. VisG is essential for biosynthesis of virginiamycin S, a streptogramin type B antibiotic, as a provider of the nonproteinogenic amino acid phenylglycine. Microbiology. 2011 Nov;157(Pt 11):3213-20.

[2]. Ge B, et al. Purification and characterization of virginiamycin M1 reductase from Streptomyces virginiae. Sci Rep. 2017 Sep 8;7(1):11017.

 Chemical & Physical Properties

Molecular Formula C43H49N7O10
Molecular Weight 823.89000
Exact Mass 823.35400
PSA 224.72000
LogP 2.06620
Vapour Pressure 0mmHg at 25°C

 Safety Information

RIDADR NONH for all modes of transport

 Articles2

More Articles
Purification and characterization of virginiamycin M1 reductase from Streptomyces virginiae.

Antimicrob. Agents Chemother. 42 , 2985-2988, (1998)

Virginiamycin M1 (VM1), produced by Streptomyces virginiae, is a polyunsaturated macrocyclic lactone antibiotic belonging to the virginiamycin A group. S. virginiae possesses an activity which stereos...

VisG is eβential for biosynthesis of virginiamycin S, a streptogramin type B antibiotic, as a provider of the nonproteinogenic amino acid phenylglycine Fitria Ningsih, Shigeru Kitani, et al.

Microbiology 167 , 3213 - 3220, (2011)

 Synonyms

virginiamycin s1 (staphylomycin s, pa 114b2, antibiotic 899, antibiotic pa 114b2, antibiotic 1745z3b, factor s )
avilamycin
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