SSM 3 trifluoroacetate
Modify Date: 2024-01-09 16:53:33
SSM 3 trifluoroacetate structure
|
Common Name | SSM 3 trifluoroacetate | ||
|---|---|---|---|---|
| CAS Number | 2320930-10-5 | Molecular Weight | 952.66 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H36F12N12O10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SSM 3 trifluoroacetateSSM3 tetraTFA is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro[1][2]. |
| Name | SSM3 tetraTFA |
|---|
| Description | SSM3 tetraTFA is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro[1][2]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 54 nM (furin) Ki: 12 nM (furin)[1] |
| In Vitro | SSM3 tetraTFA is against furin cleavage of the Pyr-RTKR-AMC substrate with an EC50 of 54 nM in vitro cleavage assays and cell-based tests[2]. SSM3 tetraTFA (0.1-25 μM) inhibits the furin-dependent conversion of PA83 into PA63 in a dose dependent manner, it inhibits PA83 processing in the cleavage reactions[2]. SSM3 tetraTFA shows comparable potency against furin (Ki=0.012 μM) and PC6B (Ki=0.004 μM), these compounds preferentially inhibited furin over PACE4 (Ki=0.041 μM) by 2- to 10-fold and over PC7 (Ki=0.595 μM) by 11- to 76-fold. In addition, it inhibits LF (Ki=1.241 μM) 25- to 167-fold less effectively than in furin and shows no measurable inhibition against trypsin and MT1-MMP[2]. |
| References |
| Molecular Formula | C30H36F12N12O10 |
|---|---|
| Molecular Weight | 952.66 |