STING agonist-23
Modify Date: 2024-01-12 22:10:17
STING agonist-23 structure
|
Common Name | STING agonist-23 | ||
|---|---|---|---|---|
| CAS Number | 2361570-16-1 | Molecular Weight | 677.72 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C33H35N13O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of STING agonist-23STING agonist-23 (CF502) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1]. |
| Name | STING agonist-23 |
|---|
| Description | STING agonist-23 (CF502) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1]. |
|---|---|
| Related Catalog | |
| In Vitro | STING agonist-23 (10 μM；3 小时或 5 小时) 处理 THP-1 细胞 3 小时后，增加磷酸化 STING、TBK1 和 IRF3 的水平；处理 THP-1 细胞 5 小时后，增加 IFN-β、IL-6、CXCL-10、TNF-α、ISG-15 和 CCL-5 的含量[1]。 |
| In Vivo | STING agonist-23 佐剂 (20μg STING agonist-23+5μg RBD-Fc/小鼠；肌肉注射；每 14 天间隔 3 次) 在小鼠模型中增强由 SARS-CoV-2 RBD-Fc 蛋白诱导的强烈抗体免疫反应[1]。 |
| References |
| Molecular Formula | C33H35N13O4 |
|---|---|
| Molecular Weight | 677.72 |