CRBN-6-5-5-VHL

Modify Date: 2025-08-27 07:19:44

CRBN-6-5-5-VHL structure	Common Name	CRBN-6-5-5-VHL
	CAS Number	2362575-45-7	Molecular Weight	972.20
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₁H₆₉N₇O₁₀S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CRBN-6-5-5-VHL

CRBN-6-5-5-VHL is a potent and selective cereblon (CRBN) degrader with a DC50 value of 1.5 nM. CRBN-6-5-5-VHL has almost no effect on the degradation of the neo-substrates IKZF1 and IKZF3[1].

Name	CRBN-6-5-5-VHL

Description	CRBN-6-5-5-VHL is a potent and selective cereblon (CRBN) degrader with a DC50 value of 1.5 nM. CRBN-6-5-5-VHL has almost no effect on the degradation of the neo-substrates IKZF1 and IKZF3[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC
Target	Cereblon:1.5 nM (DC50)
References	[1]. Christian Steinebach, et al. PROTAC-mediated crosstalk between E3 ligases. Chem Commun (Camb). 2019 Feb 5;55(12):1821-1824.

Molecular Formula	C₅₁H₆₉N₇O₁₀S
Molecular Weight	972.20
InChIKey	LIMCHOLAKDUZDS-XARBDFOFSA-N
SMILES	Cc1ncsc1-c1ccc(CNC(=O)C2CC(O)CN2C(=O)C(NC(=O)CCCCOCCCCCOCCCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1

Hazard Codes	Xi

Name: Thermodynamic solubility of the compound in phosphate buffer at pH 7 incubated for 1 ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5105246

Name: Kinetic solubility of the compound incubated for 60 mins under shaking condition by U...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5583336

Name: Kinetic solubility of the compound incubated for 60 mins under shaking condition by U...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5583337

Name: Protac activity at CRBN/ IKZF1 in human MM1S cells assessed as IKZF1 degradation by m...
Source: ChEMBL
Target: Protein cereblon
External Id: CHEMBL4374304

Name: Distribution coefficient, logD of compound in n-Octanol/PBS at pH 7.4 incubated for 3...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5583338

Name: Induction of CRBN degradation in human MM1.S cells assessed as maximum degradation at...
Source: ChEMBL
Target: Protein cereblon
External Id: CHEMBL5224294

Name: Distribution coefficient, logD of compound in n-Octanol/PBS at pH 7.4 incubated for 3...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5583339

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.