para-TOPOLIN RIBOSIDE(pTR)

Modify Date: 2025-09-18 21:06:54

para-TOPOLIN RIBOSIDE(pTR) Structure
para-TOPOLIN RIBOSIDE(pTR) structure
Common Name para-TOPOLIN RIBOSIDE(pTR)
CAS Number 23666-24-2 Molecular Weight 387.39
Density N/A Boiling Point N/A
Molecular Formula C18H21N5O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of para-TOPOLIN RIBOSIDE(pTR)


N6-(4-Methoxybenzyl)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].

 Names

Name N6-(4-methoxybenzyl)adenosine
Synonym More Synonyms

 para-TOPOLIN RIBOSIDE(pTR) Biological Activity

Description N6-(4-Methoxybenzyl)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

[2]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.  

 Chemical & Physical Properties

Molecular Formula C18H21N5O5
Molecular Weight 387.39
Exact Mass 387.15400
PSA 134.78000
LogP 0.13150
InChIKey LZNPQLJNXKVMMY-SCFUHWHPSA-N
SMILES COc1ccc(CNc2ncnc3c2ncn3C2OC(CO)C(O)C2O)cc1

 Precursor & DownStream

Precursor  0

DownStream  1

 para-TOPOLIN RIBOSIDE(pTR)Bioassay

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Name: Molar potency ratio (MPR) against A2 adenosine receptor of coronary artery
Source: ChEMBL
Target: Adenosine receptor A2a
External Id: CHEMBL639502
Name: Index of hydrophobicity (k')
Source: ChEMBL
Target: N/A
External Id: CHEMBL638342
Name: Acidic dissociation constant(pKa) against A2 adenosine receptor of coronary artery
Source: ChEMBL
Target: Adenosine receptor A2a
External Id: CHEMBL639504
Name: Cytokinin activity in Amaranthus cotyledons assessed as dark induction of betacyanin ...
Source: ChEMBL
Target: Amaranthus
External Id: CHEMBL905598
Name: Cytokinin activity in tobacco assessed as stimulation of callus growth at at 1 umol/L...
Source: ChEMBL
Target: Nicotiana tabacum
External Id: CHEMBL905604
Name: Inhibition of Trypanosoma brucei phosphoglycerate kinase (PGK); inactive at 4 mM
Source: ChEMBL
Target: Phosphoglycerate kinase 1
External Id: CHEMBL766247
Name: Activation of Arabidopsis thaliana AHK3 cytokinin receptor relative to trans-zeatin
Source: ChEMBL
Target: Histidine kinase 3
External Id: CHEMBL905605
Name: Activation of Arabidopsis thaliana CRE1/AHK4 cytokinin receptor relative to trans-zea...
Source: ChEMBL
Target: Histidine kinase 4
External Id: CHEMBL905606
Name: Cytokinin activity in wheat assessed as retention of chlorophyll in excised wheat lea...
Source: ChEMBL
Target: Triticum aestivum
External Id: CHEMBL905600
Name: Antitumor activity against human HL60 cells after 72 hrs by Calcein AM assay
Source: ChEMBL
Target: HL-60
External Id: CHEMBL905611
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 Synonyms

para-topolin riboside
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