para-TOPOLIN RIBOSIDE(pTR)

• 常用名: para-TOPOLIN RIBOSIDE(pTR)
• 英文名: para-TOPOLIN RIBOSIDE(pTR)
• CAS号: 23666-24-2
• 分子量: 387.39
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₂₁N₅O₅
• 熔点: N/A
• 闪点: N/A

para-TOPOLIN RIBOSIDE(pTR)用途

N6-(4-甲氧基苄基)腺苷是一种腺苷类似物。腺苷类似物主要起到平滑肌血管扩张剂的作用,也被证明可以抑制癌症的进展。其受欢迎的产品有磷酸腺苷、阿卡地辛(HY-13417)、氯法拉滨(HY-A0005)、磷酸氟达拉滨(HY-B0028)和维达拉宾(HY-B0277)[1]。

para-TOPOLIN RIBOSIDE(pTR)名称

• 英文名: N6-(4-methoxybenzyl)adenosine

para-TOPOLIN RIBOSIDE(pTR)生物活性

• 描述: N6-(4-甲氧基苄基)腺苷是一种腺苷类似物。腺苷类似物主要起到平滑肌血管扩张剂的作用,也被证明可以抑制癌症的进展。其受欢迎的产品有磷酸腺苷、阿卡地辛(HY-13417)、氯法拉滨(HY-A0005)、磷酸氟达拉滨(HY-B0028)和维达拉宾(HY-B0277)[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

  [2]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.

para-TOPOLIN RIBOSIDE(pTR)物理化学性质

• 分子式: C₁₈H₂₁N₅O₅
• 分子量: 387.39
• 精确质量: 387.15400
• PSA: 134.78000
• LogP: 0.13150
• InChIKey: LZNPQLJNXKVMMY-SCFUHWHPSA-N
• SMILES: COc1ccc(CNc2ncnc3c2ncn3C2OC(CO)C(O)C2O)cc1

para-TOPOLIN RIBOSIDE(pTR)靶点实验

查看更多实验

实验名称：Molar potency ratio (MPR) against A2 adenosine receptor of coronary artery 来源：ChEMBL 靶标：Adenosine receptor A2a External Id：CHEMBL639502

实验名称：Index of hydrophobicity (k') 来源：ChEMBL 靶标：N/A External Id：CHEMBL638342

实验名称：Acidic dissociation constant(pKa) against A2 adenosine receptor of coronary artery 来源：ChEMBL 靶标：Adenosine receptor A2a External Id：CHEMBL639504

实验名称：Cytokinin activity in Amaranthus cotyledons assessed as dark induction of betacyanin ... 来源：ChEMBL 靶标：Amaranthus External Id：CHEMBL905598

实验名称：Cytokinin activity in tobacco assessed as stimulation of callus growth at at 1 umol/L... 来源：ChEMBL 靶标：Nicotiana tabacum External Id：CHEMBL905604

实验名称：Inhibition of Trypanosoma brucei phosphoglycerate kinase (PGK); inactive at 4 mM 来源：ChEMBL 靶标：Phosphoglycerate kinase 1 External Id：CHEMBL766247

实验名称：Activation of Arabidopsis thaliana AHK3 cytokinin receptor relative to trans-zeatin 来源：ChEMBL 靶标：Histidine kinase 3 External Id：CHEMBL905605

实验名称：Activation of Arabidopsis thaliana CRE1/AHK4 cytokinin receptor relative to trans-zea... 来源：ChEMBL 靶标：Histidine kinase 4 External Id：CHEMBL905606

实验名称：Cytokinin activity in wheat assessed as retention of chlorophyll in excised wheat lea... 来源：ChEMBL 靶标：Triticum aestivum External Id：CHEMBL905600

实验名称：Antitumor activity against human HL60 cells after 72 hrs by Calcein AM assay 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL905611

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para-TOPOLIN RIBOSIDE(pTR)英文别名

• para-topolin riboside