8H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one,10-methoxy

Modify Date: 2025-08-28 08:45:36

8H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one,10-methoxy structure	Common Name	8H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one,10-methoxy
	CAS Number	23740-25-2	Molecular Weight	305.28
	Density	1.472g/cm3	Boiling Point	572.5ºC at 760mmHg
	Molecular Formula	C₁₈H₁₁NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	300.1ºC

Use of 8H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one,10-methoxy

Lanuginosine (Compound 12) is an AChE inhibitor (IC50: 10.9 μM). Lanuginosine inhibits Aβ aggregation. Lanuginosine can be used for research of Alzheimer’s disease[1].

Name	lanuginosine
Synonym	More Synonyms

Description	Lanuginosine (Compound 12) is an AChE inhibitor (IC50: 10.9 μM). Lanuginosine inhibits Aβ aggregation. Lanuginosine can be used for research of Alzheimer’s disease[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	10.9 μM (AChE)[1]
References	[1]. Jiang K, et al. Bioactive Isoquinoline Alkaloids with Diverse Skeletons from Fissistigma polyanthum. J Nat Prod. 2023 Aug 24.

Density	1.472g/cm3
Boiling Point	572.5ºC at 760mmHg
Molecular Formula	C₁₈H₁₁NO₄
Molecular Weight	305.28
Flash Point	300.1ºC
Exact Mass	305.06900
PSA	57.65000
LogP	3.18350
Vapour Pressure	4.07E-13mmHg at 25°C
Index of Refraction	1.729
InChIKey	WLXLLQQGGGHOMA-UHFFFAOYSA-N
SMILES	COc1ccc2c(c1)C(=O)c1nccc3cc4c(c-2c13)OCO4

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RB6035500

CHEMICAL NAME :: Noraporphin-7-one, 4,5,6,6a-tetradehydro-9-methoxy-1,2-(methylenedioxy)-

CAS REGISTRY NUMBER :: 23740-25-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H11-N-O4

MOLECULAR WEIGHT :: 305.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 3 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 240,267,1990

HS Code	2934999090

10-methoxy-7-me...

CAS#:28360-52-3

8H-Benzo[g]-1,3...

CAS#:23740-25-2

Literature: Govindachari,T.R. et al. Indian Journal of Chemistry, 1970 , vol. 8, p. 475 - 477

Precursor 1
CAS#:28360-52-3 10-methoxy-7-me...
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Name: Inhibition of amyloid beta 42 (unknown origin) aggregation assessed as reduction in a...
Source: ChEMBL
Target: Amyloid-beta precursor protein
External Id: CHEMBL5390771

Name: Inhibition of amyloid beta 42 (unknown origin) aggregation at 50 uM incubated for 24 ...
Source: ChEMBL
Target: Amyloid-beta precursor protein
External Id: CHEMBL5390770

Name: Selectivity ratio, ratio of inhibition of BChE (unknown origin) to inhibition of AChE...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5390769

Name: Cytotoxicity against human HepG2 cells
Source: ChEMBL
Target: HepG2
External Id: CHEMBL944430

Name: Inhibition of BChE (unknown origin) using BTCI as substrate preincubated for 15 min f...
Source: ChEMBL
Target: Cholinesterase
External Id: CHEMBL5390768

Name: Inhibition of AChE (unknown origin) using ATCI as substrate preincubated for 15 min f...
Source: ChEMBL
Target: Acetylcholinesterase
External Id: CHEMBL5390767

Name: Selectivity index, ratio of CC50 for BALB/c mouse spleen cells to IC50 for BALB/c mou...
Source: ChEMBL
Target: N/A
External Id: CHEMBL915968

Name: Selectivity index, ratio of CC50 for BALB/c mouse T cells to IC50 for BALB/c mouse B ...
Source: ChEMBL
Target: T-cell
External Id: CHEMBL915969

Name: Inhibition of thrombin-mediated conversion of fibrinogen to fibrin
Source: ChEMBL
Target: Prothrombin
External Id: CHEMBL944432

Name: Cytotoxicity against BALB/c mouse spleen cells
Source: ChEMBL
Target: N/A
External Id: CHEMBL916517

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10-Methoxy-8H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one

Oxoxylopine

10-methoxy-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinolin-8-one

9-METHOXY-1,2-METHYLENEDIOXY-7-OXAPORPHINE

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Use of 8H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one,10-methoxy

Names

Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Bioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.