RB-3

Modify Date: 2024-01-09 19:19:20

RB-3 Structure
RB-3 structure
Common Name RB-3
CAS Number 2396639-11-3 Molecular Weight 417.89
Density N/A Boiling Point N/A
Molecular Formula C24H20ClN3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RB-3


RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM[1].

 Names

Name RB-3

 RB-3 Biological Activity

Description RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM[1].
Related Catalog
Target

Kd: 2.8 μM (RING1B-BMI1f)[1].

In Vitro RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples[1]. RB-3 inhibits H2A ubiquitination with an IC50 of 1.6 μM[1]. RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes[1]. RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model[1]. Western Blot Analysis[1] Cell Line: TEX cells. Concentration: 6, 12, 25 μM. Incubation Time: 8d. Result: Dose-dependently increased C/EBPα-p42 protein levels.
References

[1]. Shirish Shukla, et al. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat Chem Biol. 2021 Jul;17(7):784-793.

 Chemical & Physical Properties

Molecular Formula C24H20ClN3O2
Molecular Weight 417.89
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