Adaphostin
Modify Date: 2026-08-15 17:08:36
Adaphostin structure
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Common Name | Adaphostin | ||
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| CAS Number | 241127-58-2 | Molecular Weight | 393.47500 | |
| Density | 1.33g/cm3 | Boiling Point | 606.2ºC at 760mmHg | |
| Molecular Formula | C24H27NO4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 320.4ºC | |
Use of AdaphostinAdaphostin (NSC 680410), the adamantyl ester of AG957, is a potent p210bcr/abl inhibitor (IC50=14 μM). Adaphostin induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 ranging from 17 to 216 nM). Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Adaphostin increased the level of reactive oxygen species (ROS) within CLL B cells[1][2][3]. |
| Name | 1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate |
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| Synonym | More Synonyms |
| Description | Adaphostin (NSC 680410), the adamantyl ester of AG957, is a potent p210bcr/abl inhibitor (IC50=14 μM). Adaphostin induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 ranging from 17 to 216 nM). Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Adaphostin increased the level of reactive oxygen species (ROS) within CLL B cells[1][2][3]. |
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| Related Catalog | |
| In Vitro | Adaphostin down-regulates p210bcr/abl in K562 cells and inhibits granulocyte colony formation in chronic myelogenous leukemia (CML) specimens at lower concentrations without enhanced toxicity in normal progenitors[1]. Adaphostin-induced p53 up-regulation, DNA strand breaks, and ROS production in ML-1 cells is inhibited by N-acetylcysteine (NAC)[4]. |
| References |
| Density | 1.33g/cm3 |
|---|---|
| Boiling Point | 606.2ºC at 760mmHg |
| Molecular Formula | C24H27NO4 |
| Molecular Weight | 393.47500 |
| Flash Point | 320.4ºC |
| Exact Mass | 393.19400 |
| PSA | 70.00000 |
| LogP | 4.99130 |
| Vapour Pressure | 2.73E-15mmHg at 25°C |
| Index of Refraction | 1.661 |
| InChIKey | YJZSUCFGHXQWDM-UHFFFAOYSA-N |
| SMILES | O=C(OC12CC3CC(CC(C3)C1)C2)c1ccc(NCc2cc(O)ccc2O)cc1 |
| RIDADR | NONH for all modes of transport |
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Adaphostin CAS#:241127-58-2 |
| Literature: Bioorganic and Medicinal Chemistry, , vol. 13, # 5 p. 1749 - 1761 |
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Adaphostin CAS#:241127-58-2 |
| Literature: Bioorganic and Medicinal Chemistry, , vol. 13, # 5 p. 1749 - 1761 |
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Adaphostin CAS#:241127-58-2 |
| Literature: Bioorganic and Medicinal Chemistry, , vol. 13, # 5 p. 1749 - 1761 |
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~%
Adaphostin CAS#:241127-58-2 |
| Literature: Bioorganic and Medicinal Chemistry, , vol. 13, # 5 p. 1749 - 1761 |
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Adaphostin CAS#:241127-58-2 |
| Literature: Bioorganic and Medicinal Chemistry, , vol. 13, # 5 p. 1749 - 1761 |
| Precursor 3 | |
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| DownStream 0 | |
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
|
|
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
|
|
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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|
Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
|
|
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
|
|
Name: uHTS identification of small molecule modulators of NR3A
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: SBCCG-A1015-NR3A-Primary-Assay
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|
Name: uHTS identification of small molecule modulators of Rev-erb Alpha.
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: SBCCG-A1016-RevErbaLBD-Primary-Assay
|
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Name: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint...
Source: Broad Institute
Target: N/A
External Id: 2084-01_Activator_SinglePoint_HTS_Activity
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| tyrphostin AG957 adamantyl ester |
| 4'-adamantylbenzoate-1'-N-1,4-dihydroxybenzylamine |
| AG 957,Adamantyl Ester |
| Adaphostin |