HCV-IN-37

Modify Date: 2025-09-11 18:47:06

HCV-IN-37 structure	Common Name	HCV-IN-37
	CAS Number	2425804-98-2	Molecular Weight	515.64
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₃₅F₂N₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HCV-IN-37

HCV-IN-37 (Compound 3d) is a potent inhibitor of HCV. HCV-IN-37 is orally available and long-lasting in rat plasma after oral administration to rats by a single dose of 15 mg/kg. The high potency of active derivative HCV-IN-37 is primarily driven by the inhibitory effect on the virus entry stage[1].

Name	HCV-IN-37

Description	HCV-IN-37 (Compound 3d) is a potent inhibitor of HCV. HCV-IN-37 is orally available and long-lasting in rat plasma after oral administration to rats by a single dose of 15 mg/kg. The high potency of active derivative HCV-IN-37 is primarily driven by the inhibitory effect on the virus entry stage[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection
Target	EC50: 0.005 ± 0.005 μM (HCV)[1]
References	[1]. Wang Y, et al. Design, Synthesis, and Biological Evaluation of 2-((4-Bisarylmethyl-piperazin-1-yl)methyl)benzonitrile Derivatives as HCV Entry Inhibitors. J Med Chem. 2022 Feb 10;65(3):2107-2121.

Molecular Formula	C₃₁H₃₅F₂N₅
Molecular Weight	515.64
InChIKey	ISBMZADUBPHPBL-UHFFFAOYSA-N
SMILES	CN1CCCN(c2ccc(C#N)c(CN3CCN(C(c4ccc(F)cc4)c4ccc(F)cc4)CC3)c2)CC1

Name: MRT in Sprague-Dawley rat at 15 mg/kg, po administered as single dose measured upto 2...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5041680

Name: AUC (0 to infinity) in Sprague-Dawley rat at 15 mg/kg, po administered as single dose...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5041684

Name: Selectivity index, ratio of CC50 for cytotoxicity against human Huh7.5.1 cells to EC5...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5041683

Name: Antiviral activity against HCV infected in human Huh7.5 cells incubated for 72 hrs by...
Source: ChEMBL
Target: Hepacivirus hominis
External Id: CHEMBL5041682

Name: Cytotoxicity against human Huh7.5 cells assessed as reduction in cell viability incub...
Source: ChEMBL
Target: Huh-7.5
External Id: CHEMBL5041681

Name: Antiviral activity against HCV infected in human Huh7.5 cells assessed as reduction i...
Source: ChEMBL
Target: Hepacivirus hominis
External Id: CHEMBL5041704

Name: Antiviral activity against HCV infected in human Huh7.5 cells assessed as reduction i...
Source: ChEMBL
Target: Hepacivirus hominis
External Id: CHEMBL5041703

Name: Selectivity index, ratio of CC50 for cytotoxicity against human Huh7.5 cells infected...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5041702

Name: Antiviral activity against HCV infected in human Huh7.5 cells carrying HCV subgenomic...
Source: ChEMBL
Target: Hepacivirus hominis
External Id: CHEMBL5041701

Name: Antiviral activity against HCV infected in human Huh7.5 cells assessed as reduction i...
Source: ChEMBL
Target: Hepacivirus hominis
External Id: CHEMBL5041696

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HCV-IN-37

Use of HCV-IN-37

Names

HCV-IN-37 Biological Activity

Chemical & Physical Properties

HCV-IN-37Bioassay

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.