NLRP3-IN-20

Modify Date: 2024-01-02 11:37:13

NLRP3-IN-20 structure	Common Name	NLRP3-IN-20
	CAS Number	2428478-22-0	Molecular Weight	413.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₇N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NLRP3-IN-20

NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis[1].

Name	NLRP3-IN-20

Description	NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
Target	NLRP3[1]
References	[1]. Li Z, et al. Novel Sulfonylurea-Based NLRP3 Inflammasome Inhibitor for Efficient Treatment of Nonalcoholic Steatohepatitis, Endotoxic Shock, and Colitis. J Med Chem. 2023 Sep 11.. .

Molecular Formula	C₂₂H₂₇N₃O₃S
Molecular Weight	413.53

NLRP3-IN-20

Use of NLRP3-IN-20

Names

NLRP3-IN-20 Biological Activity

Chemical & Physical Properties