NLRP3-IN-20
Modify Date: 2024-01-02 11:37:13
NLRP3-IN-20 structure
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Common Name | NLRP3-IN-20 | ||
|---|---|---|---|---|
| CAS Number | 2428478-22-0 | Molecular Weight | 413.53 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H27N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NLRP3-IN-20NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis[1]. |
| Name | NLRP3-IN-20 |
|---|
| Description | NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis[1]. |
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| Related Catalog | |
| Target |
NLRP3[1] |
| References |
| Molecular Formula | C22H27N3O3S |
|---|---|
| Molecular Weight | 413.53 |
| InChIKey | WHENNLLCPPZNFB-UHFFFAOYSA-N |
| SMILES | CN(C)Cc1ccc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)cc1 |