Indirubin-5-sulfonate

Modify Date: 2024-01-10 18:34:58

Indirubin-5-sulfonate structure	Common Name	Indirubin-5-sulfonate
	CAS Number	244021-67-8	Molecular Weight	342.33
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₀N₂O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Indirubin-5-sulfonate

Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively[1]. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β[2].

Name	Indirubin-5-sulfonate

Description	Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively[1]. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β[2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	Cdk1/cyclin B:55 nM (IC50) cdk2/cyclin A:35 nM (IC50) CDK2/cyclinE:150 nM (IC50) Cdk4/cyclin D1:300 nM (IC50) CDK5/p35:65 nM (IC50) GSK-3β
References	[1]. Hoessel R, et al. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol. 1999 May;1(1):60-7. [2]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60.

Molecular Formula	C₁₆H₁₀N₂O₅S
Molecular Weight	342.33

Indirubin-5-sulfonate

Use of Indirubin-5-sulfonate

Names

Indirubin-5-sulfonate Biological Activity

Chemical & Physical Properties