BBR-BODIPY
Modify Date: 2024-04-05 19:47:28
BBR-BODIPY structure
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Common Name | BBR-BODIPY | ||
|---|---|---|---|---|
| CAS Number | 2456476-47-2 | Molecular Weight | 861.18 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C47H48BClF2N6O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BBR-BODIPYBBR-BODIPY is a fluorescent probe that allows screening its interaction with the targeted cells. BBR-BODIPY induces apoptosis and changes the expression of apoptosis-related proteins[1]. |
| Name | BBR-BODIPY |
|---|
| Description | BBR-BODIPY is a fluorescent probe that allows screening its interaction with the targeted cells. BBR-BODIPY induces apoptosis and changes the expression of apoptosis-related proteins[1]. |
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| Related Catalog | |
| Target |
Bax Caspase-9 |
| In Vitro | BBR-BODIPY (1-32 μM; 24 hours; MCF7 and MDA-MB-231 cells) has anti-proliferative activity[1]. BBR-BODIPY (2-16 μM; 5-60 mins; MCF7 cells) could be quickly taken up into MCF7 cells in 5 mins and the fluorescence intensity exhibits a time-dependent manner[1]. BBR-BODIPY (1-32 μM; 24 hours; MCF7 and MDA-MB-231 cells) accumulates in mitochondria and overlaps with Mito tracker red to display yellow fluorescence with a Pearsons co-localization coefficient of 0.72[1]. BBR-BODIPY (8 μM, 12 hours) induces apoptosis in MCF7 cells through a mitochondrial pathway[1]. Cell Cytotoxicity Assay[1] Cell Line: MCF7 and MDA-MB-231 cells Concentration: 1 , 2 , 4 , 8 , 16 and 32 μM Incubation Time: 24 hours Result: Inhibited with IC50 values of 40.81 and 41.46 μM for MCF7 and MDA-MB-231 cells, respectively. Western Blot Analysis[1] Cell Line: MCF7 cells Concentration: 8 μM Incubation Time: 12 hours Result: The amounts of Bax and Cyto C released from mitochondria and cleaved Caspase 9 were up-regulated in MCF7 cells. |
| References |
| Molecular Formula | C47H48BClF2N6O5 |
|---|---|
| Molecular Weight | 861.18 |