Lenperone Hydrochloride

Modify Date: 2025-08-25 12:53:22

Lenperone Hydrochloride structure	Common Name	Lenperone Hydrochloride
	CAS Number	24677-86-9	Molecular Weight	407.88100
	Density	1.186g/cm3	Boiling Point	507.9ºC at 760mmHg
	Molecular Formula	C₂₂H₂₄ClF₂NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	261ºC

Use of Lenperone Hydrochloride

Lenperone hydrochloride (AHR 2277) is an antipsychotic compound and a dopamine antagonist. Lenperone hydrochloride reduces gastroesophageal sphincter pressure of healthy dogs. Lenperone hydrochloride can be used for neurological disease research[1][2].

Name	Lenperone hydrochloride
Synonym	More Synonyms

Description	Lenperone hydrochloride (AHR 2277) is an antipsychotic compound and a dopamine antagonist. Lenperone hydrochloride reduces gastroesophageal sphincter pressure of healthy dogs. Lenperone hydrochloride can be used for neurological disease research[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
In Vivo	Lenperone hydrochloride (0.16 和 0.44 mg/kg；肌内注射；一次) 降低健康犬的平均值胃食管括约肌压力 (GESP)[1]。 Lenperone hydrochloride (0.5，1.0 和 2.0 mg/kg；皮下注射) 在脑损伤大鼠中显示抗精神疾病的作用，诱导剂量依赖的镇静状态并减少双侧间质核、终纹[2]。 Animal Model: Healthy adult dogs[1] Dosage: 0.16 and 0.44 mg/kg Administration: Intramuscular injection; 0.16 and 0.44 mg/kg, once Result: Effectively decreased gastroesophageal sphincter pressure (GESP) of dogs.
References	[1]. Johnson SE, et al. Effect of lenperone hydrochloride on gastroesophageal sphincter pressure in healthy dogs. Can J Vet Res. 1989 Apr;53(2):248-50. [2]. Costall B, Naylor RJ. Mesolimbic involvement with behavioural effects indicating antipsychotic activity. Eur J Pharmacol. 1974 Jun;27(1):46-58.

Density	1.186g/cm3
Boiling Point	507.9ºC at 760mmHg
Molecular Formula	C₂₂H₂₄ClF₂NO₂
Molecular Weight	407.88100
Flash Point	261ºC
Exact Mass	407.14600
PSA	37.38000
LogP	5.26250

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EU2456000

CHEMICAL NAME :: Butyrophenone, 4-(4-(p-fluorobenzoyl)piperidino)-4'-fluoro-, hydrochloride

CAS REGISTRY NUMBER :: 24677-86-9

LAST UPDATED :: 198812

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H23-F2-N-O2.Cl-H

MOLECULAR WEIGHT :: 407.92

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,1,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,1,1970

ahr-2277

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China
Product Name: Palmitic acid
Price: Check
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China
Product Name: Lenperone Hydrochloride
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Butanone,4-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-(4-fluorophenyl)-, hydrochloride (1:1)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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CHEMICAL IDENTIFICATION

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ACUTE TOXICITY DATA

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.