H-Arg-Gln-OH hydrochloride salt

Modify Date: 2024-01-07 17:30:27

H-Arg-Gln-OH hydrochloride salt structure	Common Name	H-Arg-Gln-OH hydrochloride salt
	CAS Number	2483-17-2	Molecular Weight	302.33
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₂₂N₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of H-Arg-Gln-OH hydrochloride salt

Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy[1].

Name	(2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid
Synonym	More Synonyms

Description	Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGF[1]
In Vitro	Arginyl-Glutamine (0.5-1.5 mM; 48 h) 会导致人类 RPE 细胞中可溶性 VEGF 在培养基中的表达呈统计学意义上的剂量依赖性下降[1]。
In Vivo	Arginyl-Glutamine (1-5 g/kg/day as a hydrochloride salt; i.p.; twice daily) 显著抑制小鼠氧诱导视网膜病变 (OIR) 模型中的视网膜新生血管[1]。 Animal Model: C57BL6/J mouse pups, oxygen-induced retinopathy (OIR) model[1] Dosage: 1.0, 2.5, or 5 g/kg per day Administration: Intraperitoneal injection, twice daily Result: Significantly decreased preretinal nuclei. Reduced neovascular tufts and vascular leakage in retinal vessels. Reduced preretinal neovascularization by 82% ± 7% and reduced VEGF mRNA by 64% ± 9% at 5 g/kg per day.
References	[1]. Neu J, et al. The dipeptide Arg-Gln inhibits retinal neovascularization in the mouse model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3151-5.

Molecular Formula	C₁₁H₂₂N₆O₄
Molecular Weight	302.33
Exact Mass	338.14700
PSA	197.41000
LogP	1.19630

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H-ARG-GLN-OH

GL Biochem (Shanghai) Ltd.
China
Product Name: H-Arg-Gln-OH
Price: $Inquiry/1kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

Nanjing Peptide Biotech Ltd
China
Product Name: H-Arg-Gln-OH
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

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H-Arg-Gln-OH hydrochloride salt

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