H-Arg-Gln-OH hydrochloride salt
Modify Date: 2026-07-05 09:23:02
H-Arg-Gln-OH hydrochloride salt structure
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Common Name | H-Arg-Gln-OH hydrochloride salt | ||
|---|---|---|---|---|
| CAS Number | 2483-17-2 | Molecular Weight | 302.33 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H22N6O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of H-Arg-Gln-OH hydrochloride saltArginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy[1]. |
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| Related Catalog | |
| Target |
VEGF[1] |
| In Vitro | Arginyl-Glutamine (0.5-1.5 mM; 48 h) 会导致人类 RPE 细胞中可溶性 VEGF 在培养基中的表达呈统计学意义上的剂量依赖性下降[1]。 |
| In Vivo | Arginyl-Glutamine (1-5 g/kg/day as a hydrochloride salt; i.p.; twice daily) 显著抑制小鼠氧诱导视网膜病变 (OIR) 模型中的视网膜新生血管[1]。 Animal Model: C57BL6/J mouse pups, oxygen-induced retinopathy (OIR) model[1] Dosage: 1.0, 2.5, or 5 g/kg per day Administration: Intraperitoneal injection, twice daily Result: Significantly decreased preretinal nuclei. Reduced neovascular tufts and vascular leakage in retinal vessels. Reduced preretinal neovascularization by 82% ± 7% and reduced VEGF mRNA by 64% ± 9% at 5 g/kg per day. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C11H22N6O4 |
|---|---|
| Molecular Weight | 302.33 |
| Exact Mass | 338.14700 |
| PSA | 197.41000 |
| LogP | 1.19630 |
| InChIKey | PMGDADKJMCOXHX-BQBZGAKWSA-N |
| SMILES | NC(=O)CCC(NC(=O)C(N)CCCN=C(N)N)C(=O)O |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| L-Arginyl-L-glutamin-acetat |
| Arginylglutamine |
| Glutamine,N2-L-arginyl-(6CI,7CI) |
| L-Arg-L-Gln |
| L-Glutamine,N2-L-arginyl |
| L-Glutamine,L-arginyl |
| Glutamine,N2-L-arginyl-,L-(8CI) |
| N2-L-Arginyl-L-glutamin |
| N2-L-arginyl-L-glutamine |
| L-Arginyl=>L-glutamin |
| L-arginyl-L-glutamine |
| H-ARG-GLN-OH |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the LogP of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid? |
| A: LogP of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid is 1.19630. |
| Q: What is the polar surface area (PSA) of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid? |
| A: Polar surface area (PSA) of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid is 197.41000. |
| Q: What is the molecular weight of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid? |
| A: Molecular weight of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid is 302.33. |
| Q: What is the InChIKey of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid? |
| A: InChIKey of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid is PMGDADKJMCOXHX-BQBZGAKWSA-N. |
| Q: What is the English name of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid? |
| A: The English name of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid is (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid. |
| Q: What English synonyms does (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid have? |
| A: English synonyms of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid: L-Arginyl-L-glutamin-acetat, Arginylglutamine, Glutamine,N2-L-arginyl-(6CI,7CI), L-Arg-L-Gln, L-Glutamine,N2-L-arginyl, L-Glutamine,L-arginyl, Glutamine,N2-L-arginyl-,L-(8CI), N2-L-Arginyl-L-glutamin, N2-L-arginyl-L-glutamine, L-Arginyl=>L-glutamin, L-arginyl-L-glutamine, H-ARG-GLN-OH. |
| Q: What is the CAS number of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid? |
| A: CAS number of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid is 2483-17-2. |
| Q: What is the SMILES notation of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid? |
| A: SMILES notation of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid is NC(=O)CCC(NC(=O)C(N)CCCN=C(N)N)C(=O)O. |
| Q: What is the molecular formula of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid? |
| A: Molecular formula of (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid is C11H22N6O4. |
| Q: What is the Chinese name of 2483-17-2? |
| A: Chinese name of 2483-17-2 is 2483-17-2. |