2483-17-2

2483-17-2 structure

Name: H-Arg-Gln-OH hydrochloride salt
Chemical Name: (2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid
CAS Number: 2483-17-2
Molecular Formula: C₁₁H₂₂N₆O₄
Molecular Weight: 302.33
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
Create Date: 2016-08-04 07:10:44
Modify Date: 2025-08-24 18:21:31
Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy[1].

Name	(2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid
Synonyms	L-Arginyl-L-glutamin-acetat Arginylglutamine Glutamine,N2-L-arginyl-(6CI,7CI) L-Arg-L-Gln L-Glutamine,N2-L-arginyl L-Glutamine,L-arginyl Glutamine,N2-L-arginyl-,L-(8CI) N2-L-Arginyl-L-glutamin N2-L-arginyl-L-glutamine L-Arginyl=>L-glutamin L-arginyl-L-glutamine H-ARG-GLN-OH

Description	Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGF[1]
In Vitro	Arginyl-Glutamine (0.5-1.5 mM; 48 h) 会导致人类 RPE 细胞中可溶性 VEGF 在培养基中的表达呈统计学意义上的剂量依赖性下降[1]。
In Vivo	Arginyl-Glutamine (1-5 g/kg/day as a hydrochloride salt; i.p.; twice daily) 显著抑制小鼠氧诱导视网膜病变 (OIR) 模型中的视网膜新生血管[1]。 Animal Model: C57BL6/J mouse pups, oxygen-induced retinopathy (OIR) model[1] Dosage: 1.0, 2.5, or 5 g/kg per day Administration: Intraperitoneal injection, twice daily Result: Significantly decreased preretinal nuclei. Reduced neovascular tufts and vascular leakage in retinal vessels. Reduced preretinal neovascularization by 82% ± 7% and reduced VEGF mRNA by 64% ± 9% at 5 g/kg per day.
References	[1]. Neu J, et al. The dipeptide Arg-Gln inhibits retinal neovascularization in the mouse model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3151-5.