EZH2-IN-17

Modify Date: 2024-01-20 19:30:38

EZH2-IN-17 Structure
EZH2-IN-17 structure
Common Name EZH2-IN-17
CAS Number 2489672-09-3 Molecular Weight 598.77
Density N/A Boiling Point N/A
Molecular Formula C36H46N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of EZH2-IN-17


EZH2-IN-17 (compound 28) is a potent and orally active EZH2 inhibitor with an IC50 value of 0.95 nM. EZH2-IN-17 exhibits high anti-proliferation activity against different lymphoma cell lines including WSU-DLCL2, Pfeiffer and Karpas-422 (IC50 values of 2.36 nM, 1.73 nM, and 1.82 nM, respectively)[1].

 Names

Name EZH2-IN-17

 EZH2-IN-17 Biological Activity

Description EZH2-IN-17 (compound 28) is a potent and orally active EZH2 inhibitor with an IC50 value of 0.95 nM. EZH2-IN-17 exhibits high anti-proliferation activity against different lymphoma cell lines including WSU-DLCL2, Pfeiffer and Karpas-422 (IC50 values of 2.36 nM, 1.73 nM, and 1.82 nM, respectively)[1].
Related Catalog
References

[1]. Xin Xu, et al. Conformationally constrained potent inhibitors for enhancer of zeste homolog 2 (EZH2). Bioorg Med Chem Lett. 2023 Nov 11:129558.  

 Chemical & Physical Properties

Molecular Formula C36H46N4O4
Molecular Weight 598.77
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