TIM-063

Modify Date: 2025-08-25 14:22:52

TIM-063 Structure
TIM-063 structure
Common Name TIM-063
CAS Number 2493978-38-2 Molecular Weight 331.287
Density N/A Boiling Point N/A
Molecular Formula C18H9N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TIM-063


TIM-063 (TIM063) is a potent, selective, ATP-competitive CaMKK inhibitor with Ki of 0.35/0.2 uM for CaMKKα and CaMKKβ, respectively.TIM-063 directly targets the catalytic domain of CaMKK, similar to STO-609.TIM-063 suppressed the ionomycin-induced phosphorylation of exogenously expressed CaMKI, CaMKIV, and endogenous AMPKα in HeLa cells with an IC50 of 0.3 uM.TIM-063 suppressed CaMKK isoform-mediated CaMKIV phosphorylation in transfected COS-7 cells.TIM-063 displayed cell permeability and the ability to inhibit CaMKK activity in cells. TIM-063 is a useful chemical probe for the precise analysis of CaMKK-mediated signaling pathways.

 Names

Name TIM-063

 TIM-063 Biological Activity

Description TIM-063 (TIM063) is a potent, selective, ATP-competitive CaMKK inhibitor with Ki of 0.35/0.2 uM for CaMKKα and CaMKKβ, respectively.TIM-063 directly targets the catalytic domain of CaMKK, similar to STO-609.TIM-063 suppressed the ionomycin-induced phosphorylation of exogenously expressed CaMKI, CaMKIV, and endogenous AMPKα in HeLa cells with an IC50 of 0.3 uM.TIM-063 suppressed CaMKK isoform-mediated CaMKIV phosphorylation in transfected COS-7 cells.TIM-063 displayed cell permeability and the ability to inhibit CaMKK activity in cells. TIM-063 is a useful chemical probe for the precise analysis of CaMKK-mediated signaling pathways.
References 1. Ohtsuka S, et al. Biochemistry. 2020 May 5;59(17):1701-1710. 2. Satomi Ohtsuka, et al. Biochemistry, March 11, 2022. 3. Toshio Kitazawa, et al. Am J Physiol Cell Physiol. 2021 Sep 1;321(3):C549-C558.

 Chemical & Physical Properties

Molecular Formula C18H9N3O4
Molecular Weight 331.287
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