CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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WL5075000
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CHEMICAL NAME :
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Styrene, methyl-
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CAS REGISTRY NUMBER :
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25013-15-4
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BEILSTEIN REFERENCE NO. :
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1209317
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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53
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MOLECULAR FORMULA :
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C9-H10
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MOLECULAR WEIGHT :
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118.19
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WISWESSER LINE NOTATION :
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1U1R X1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Human
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DOSE/DURATION :
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400 ppm
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2255 mg/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Skin and Appendages - hair
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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4500 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2324 mg/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Skin and Appendages - hair
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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3160 mg/kg
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - other changes Blood - hemorrhage
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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3020 mg/m3/4H
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - other changes Blood - hemorrhage
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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4500 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1300 ppm/6H/15D-I
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - lacrimation Liver - other changes Liver - changes in liver weight
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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332 ppm/6H/21W-I
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TOXIC EFFECTS :
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Peripheral Nerve and Sensation - recording from afferent nerve Peripheral Nerve and Sensation - recording from peripheral motor nerve
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1000 ppm/6H/13W-I
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - lacrimation Liver - changes in liver weight
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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100 ppm/6H/15W-I
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TOXIC EFFECTS :
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Peripheral Nerve and Sensation - recording from peripheral motor nerve
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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200 ppm/6H/15D-I
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - other changes Liver - hepatitis (hepatocellular necrosis), diffuse Related to Chronic Data - death
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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160 ppm/6H/13W-I
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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3750 mg/kg
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SEX/DURATION :
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female 1-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
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TYPE OF TEST :
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Micronucleus test
MUTATION DATA
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TYPE OF TEST :
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Mutation in mammalian somatic cells
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TEST SYSTEM :
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Rodent - mouse Lymphocyte
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REFERENCE :
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EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12,85,1988 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997 ACGIH TLV-STEL 483 mg/m3 (100 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 242 mg/m3 (50 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,373,1994 IARC Cancer Review:Animal Lack Carcinogenicity IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,373,1994 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,373,1994 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 100 ppm (480 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,278,1971 OSHA PEL (Gen Indu):8H TWA 100 ppm (480 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 100 ppm (480 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 100 ppm (480 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 100 ppm (480 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 50 ppm (240 mg/m3);STEL 100 ppm (485 mg/m3) JAN 1993 OEL-BELGIUM:TWA 50 ppm (242 mg/m3);STEL 100 ppm (483 mg/m3) JAN 1993 OEL-DENMARK:TWA 25 ppm (120 mg/m3) JAN 1993 OEL-FINLAND:TWA 50 ppm (240 mg/m3);STEL 100 ppm (480 mg/m3) JAN 1993 OEL-FRANCE:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-GERMANY:TWA 100 ppm (480 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 100 ppm (480 mg/m3) JAN 1993 OEL-RUSSIA:STEL 50 mg/m3 JAN 1993 OEL-SWEDEN:TWA 25 ppm (120 mg/m3);STEL 75 ppm (350 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-TURKEY:TWA 100 ppm (480 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 100 ppm (480 mg/m3);STEL 150 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO VINYL TOLUENE-air:10H TWA 100 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 76510 No. of Facilities: 7016 (estimated) No. of Industries: 61 No. of Occupations: 59 No. of Employees: 73140 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 76510 No. of Facilities: 2028 (estimated) No. of Industries: 24 No. of Occupations: 31 No. of Employees: 25353 (estimated) No. of Female Employees: 3889 (estimated)
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