NADI-351
Modify Date: 2024-01-03 09:25:40
NADI-351 structure
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Common Name | NADI-351 | ||
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| CAS Number | 2503017-11-4 | Molecular Weight | 465.518 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H20FN5O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NADI-351NADI-351 is a specific small-molecule inhibitor of Notch1 transcriptional complexes with IC50 of 8.8 uM in cellualr reporter assays.NADI-351 inhibited OE33 cell growth in single dose MTT assays (EC50= 10 uM) and, more potently, in multi-dose colony formation assays (EC50=1.3 uM)NADI-351 is 15 times more potent than IMR-1 in an NTC AlphaScreen assay.NADI-351 selectively disrupted Notch1 transcription complexes, inhibited recruitment of Notch1 to the NTC (Notch Ternary Complex) and to the HES1 promoter, and reduced Notch1 recruitment to target genes.NADI-351 inhibits tumor growth in Notch-dependent cancers and does not exert gastrointestinal toxicity associated with goblet cell metaplasia.NADI-351 selectively inhibits stem-like esophageal adenocarcinoma (EAC) cell populations. |
| Name | NADI-351 |
|---|
| Description | NADI-351 is a specific small-molecule inhibitor of Notch1 transcriptional complexes with IC50 of 8.8 uM in cellualr reporter assays.NADI-351 inhibited OE33 cell growth in single dose MTT assays (EC50= 10 uM) and, more potently, in multi-dose colony formation assays (EC50=1.3 uM)NADI-351 is 15 times more potent than IMR-1 in an NTC AlphaScreen assay.NADI-351 selectively disrupted Notch1 transcription complexes, inhibited recruitment of Notch1 to the NTC (Notch Ternary Complex) and to the HES1 promoter, and reduced Notch1 recruitment to target genes.NADI-351 inhibits tumor growth in Notch-dependent cancers and does not exert gastrointestinal toxicity associated with goblet cell metaplasia.NADI-351 selectively inhibits stem-like esophageal adenocarcinoma (EAC) cell populations. |
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| References | 1. Annamil Alvarez-Trotta, et al. Cancer Res. 2021 Jun 15;81(12):3347-3357. |
| Molecular Formula | C19H20FN5O4S2 |
|---|---|
| Molecular Weight | 465.518 |