2,3-Dioxoindoline-7-carboxylic acid

Modify Date: 2024-01-09 09:17:52

2,3-Dioxoindoline-7-carboxylic acid Structure
2,3-Dioxoindoline-7-carboxylic acid structure
Common Name 2,3-Dioxoindoline-7-carboxylic acid
CAS Number 25128-35-2 Molecular Weight 191.140
Density 1.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C9H5NO4 Melting Point 268-275ºC
MSDS N/A Flash Point N/A

 Names

Name 2,3-dioxo-1H-indole-7-carboxylic acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Melting Point 268-275ºC
Molecular Formula C9H5NO4
Molecular Weight 191.140
Exact Mass 191.021851
PSA 83.47000
LogP 1.36
Index of Refraction 1.660

 MSDS

Name: 2 3-Dioxoindoline-7-carboxylic acid tech Material Safety Data Sheet
Synonym:
CAS: 25128-35-2
Section 1 - Chemical Product MSDS Name:2 3-Dioxoindoline-7-carboxylic acid tech Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
25128-35-2 2,3-Dioxoindoline-7-carboxylic acid unlisted
Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 25128-35-2: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: brown
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 275 - 276 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C9H5NO4
Molecular Weight: 191

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 25128-35-2 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2,3-Dioxoindoline-7-carboxylic acid - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 25128-35-2: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 25128-35-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 25128-35-2 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
HS Code 2933990090

 Synthetic Route

~78%

2,3-Dioxoindoline-7-carboxylic acid Structure

2,3-Dioxoindoli...

CAS#:25128-35-2

Literature: Wakelin, Laurence P. G.; Bu, Xianyong; Eleftheriou, Alexandra; Parmar, Alpesh; Hayek, Charbel; Stewart, Bernard W. Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5790 - 5802

~%

2,3-Dioxoindoline-7-carboxylic acid Structure

2,3-Dioxoindoli...

CAS#:25128-35-2

Literature: DE320647 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 13, p. 450 Helvetica Chimica Acta, , vol. 2, p. 239

~%

2,3-Dioxoindoline-7-carboxylic acid Structure

2,3-Dioxoindoli...

CAS#:25128-35-2

Literature: Journal of Medicinal Chemistry, , vol. 46, # 26 p. 5790 - 5802

~%

2,3-Dioxoindoline-7-carboxylic acid Structure

2,3-Dioxoindoli...

CAS#:25128-35-2

Literature: Journal of Medicinal Chemistry, , vol. 40, # 13 p. 2040 - 2046

~%

2,3-Dioxoindoline-7-carboxylic acid Structure

2,3-Dioxoindoli...

CAS#:25128-35-2

Literature: Helvetica Chimica Acta, , vol. 2, p. 239

~%

2,3-Dioxoindoline-7-carboxylic acid Structure

2,3-Dioxoindoli...

CAS#:25128-35-2

Literature: Journal fuer Praktische Chemie (Leipzig), , vol. <2> 147, p. 338,340

~%

2,3-Dioxoindoline-7-carboxylic acid Structure

2,3-Dioxoindoli...

CAS#:25128-35-2

Literature: Helvetica Chimica Acta, , vol. 2, p. 239 DE313725 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 13, p. 449

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

MFCD00612492
1H-indole-2,3-dione-7-carboxylic acid
2,3-Dioxo-7-indolinecarboxylic acid
2,3-dioxoindoline-7-carboxylic acid
Isatin-7-carboxylic acid
1H-Indole-7-carboxylic acid, 2,3-dihydro-2,3-dioxo-
2,3-dioxo-2,3-dihydro-indole-7-carboxylic acid
2,3-dioxo-1H-benzo[d]azolidine-7-carboxylic acid
2,3-dioxo-2,3-dihydro-1H-indole-7-carboxylic acid
2,3-Dioxo-indolin-7-carbonsaeure
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