Enflicoxib
Modify Date: 2024-01-06 19:05:09
Enflicoxib structure
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Common Name | Enflicoxib | ||
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| CAS Number | 251442-94-1 | Molecular Weight | 405.34 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H12F5N3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EnflicoxibEnflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2). Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models[1]. |
| Name | 1-(4-aminosulphonylphenyl)-5-(2,4-difluorophenyl)-4,5-dihydro-3-trifluoromethyl-1H-pyrazole |
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| Synonym | More Synonyms |
| Description | Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2). Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models[1]. |
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| Related Catalog | |
| Target |
COX-2 |
| In Vivo | "E-6132, one of Enflicoxib (E-6087) metabolites, also inhibits COX-2. After single oral administration of 5 mg/kgof E-6087 to rats, plasma concentrations of Enflicoxib at peak time are higher than those of E-6132, suggesting that activity is mainly due to Enflicoxib[1]. Enflicoxib (E-6087) is characterized by a long elimination half-life (20-35 h), a low plasma clearance (0.10-0.22 L/h/kg) and a relatively large volume of distribution (2-6 L/kg) in rats and dogs after single oral and intravenous doses. Enflicoxib and E-6132 (a pharmacologically active metabolite) show different pharmacokinetics. The higher percentage of Enflicoxib at early times suggests that Enflicoxib is the main compound responsible for in vivo activity, although E-6132 would contribute to the activity at later times[2]." Animal Model: Male and female Wistar rats (250 g)[1] Dosage: 5 mg/kg Administration: Administered by gastric gavage (10 mL/kg); a single oral dose Result: Plasma concentrations of E-6087 at peak time are higher than those of E-6132. |
| References |
| Molecular Formula | C16H12F5N3O2S |
|---|---|
| Molecular Weight | 405.34 |
| Exact Mass | 405.05700 |
| PSA | 84.14000 |
| LogP | 4.76360 |
| 1-(4-aminosulphonylphenyl)-5-(2,4-difluorophenyl)-4,5-dihydro-3-trifluoromethyl-1H-pyrazol |
| (+/-)-1-(4-aminosulphonylphenyl)-5-(2,4-difluorophenyl)-4,5-dihydro-3-trifluoromethyl-1H-pyrazole |