Thymidine,5'-amino-5'-deoxy
Thymidine,5'-amino-5'-deoxy structure
|
Common Name | Thymidine,5'-amino-5'-deoxy | ||
|---|---|---|---|---|
| CAS Number | 25152-20-9 | Molecular Weight | 241.24 | |
| Density | 1.394 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H15N3O4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of Thymidine,5'-amino-5'-deoxy5′-Amino-5′-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
| Name | 5'-amino-5'-deoxythymidine |
|---|---|
| Synonym | More Synonyms |
| Description | 5′-Amino-5′-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.394 g/cm3 |
|---|---|
| Molecular Formula | C10H15N3O4 |
| Molecular Weight | 241.24 |
| Exact Mass | 241.10600 |
| PSA | 110.34000 |
| Index of Refraction | 1.565 |
| InChIKey | PYWLBQPICCQJFF-XLPZGREQSA-N |
| SMILES | Cc1cn(C2CC(O)C(CN)O2)c(=O)[nH]c1=O |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
|
~10%
Thymidine,5'-am... CAS#:25152-20-9 |
| Literature: Wako Pure Chemical Industries, Ltd. Patent: US2008/64868 A1, 2008 ; Location in patent: Page/Page column 10; 11 ; |
|
~%
Thymidine,5'-am... CAS#:25152-20-9 |
| Literature: Tetzlaff, Charles N.; Schwope, Ina; Bleczinski, Colleen F.; Steinberg, Joshua A.; Richert, Clemens Tetrahedron Letters, 1998 , vol. 39, # 24 p. 4215 - 4218 |
|
~%
Thymidine,5'-am... CAS#:25152-20-9 |
| Literature: Challa, Hemavathi; Bruice, Thomas C. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1475 - 1481 |
|
~%
Thymidine,5'-am... CAS#:25152-20-9 |
| Literature: Charles; Arya, Dev P. Journal of Carbohydrate Chemistry, 2005 , vol. 24, # 2 p. 145 - 160 |
|
~%
Thymidine,5'-am... CAS#:25152-20-9 |
| Literature: Druillennec, Sabine; Meudal, Herve; Roques, Bernard P.; Fournie-Zaluski, Marie-Claude Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 4 p. 627 - 632 |
CAS#:13276-53-4|
Measurement of carbamoylating activity of nitrosoureas and isocyanates by a novel high-pressure liquid chromatography assay.
Biochem. Pharmacol. 35(14) , 2359-65, (1986) A new assay for carbamoylating activity using reversed phase liquid chromatography (HPLC) is described which offers several advantages over existing assays. A comparison was made of the extent of carb... |
|
|
Novel acyclic amide-conjugated nucleosides and their analogues.
Nucleosides Nucleotides Nucleic Acids 28 , 103-117, (2009) An effective one-step synthesis of new amide-conjugated nucleosides and their analogues, in the presence of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) as the condensin... |
|
|
Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas and corresponding phenyl isocyanates to 5'-amino-5'-deoxythymidine: importance of carbamoylation in mouse skin carcinogenic processes.
Carcinogenesis 13(4) , 699-702, (1992) Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas (I-X: X = -OCH3, -CH3, -H, -Cl, and -COCH3) and of their corresponding phenyl isocyanates (II-X: X = -OCH3, -CH3, -H, -Cl and -COCH3) to the... |
| 5'-Amino-5'-deoxy-D-thymidine |
| 5'-amino-3'-hydroxythymidine |
| 5'-amino-5'-deoxy-thymidine |
| 5'-deoxy-5'-aminothymidine |
| 5'-deoxy-5'-amino-deoxythymidine |