Thymidine,5'-amino-5'-deoxy
Thymidine,5'-amino-5'-deoxy structure
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Common Name | Thymidine,5'-amino-5'-deoxy | ||
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| CAS Number | 25152-20-9 | Molecular Weight | 241.24 | |
| Density | 1.394 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H15N3O4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of Thymidine,5'-amino-5'-deoxy5′-Amino-5′-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 5'-amino-5'-deoxythymidine |
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| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | 5′-Amino-5′-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.394 g/cm3 |
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| Molecular Formula | C10H15N3O4 |
| Molecular Weight | 241.24 |
| Exact Mass | 241.10600 |
| PSA | 110.34000 |
| Index of Refraction | 1.565 |
| InChIKey | PYWLBQPICCQJFF-XLPZGREQSA-N |
| SMILES | Cc1cn(C2CC(O)C(CN)O2)c(=O)[nH]c1=O |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~10%
Thymidine,5'-am... CAS#:25152-20-9 |
| Literature: Wako Pure Chemical Industries, Ltd. Patent: US2008/64868 A1, 2008 ; Location in patent: Page/Page column 10; 11 ; |
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~%
Thymidine,5'-am... CAS#:25152-20-9 |
| Literature: Tetzlaff, Charles N.; Schwope, Ina; Bleczinski, Colleen F.; Steinberg, Joshua A.; Richert, Clemens Tetrahedron Letters, 1998 , vol. 39, # 24 p. 4215 - 4218 |
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~%
Thymidine,5'-am... CAS#:25152-20-9 |
| Literature: Challa, Hemavathi; Bruice, Thomas C. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1475 - 1481 |
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~%
Thymidine,5'-am... CAS#:25152-20-9 |
| Literature: Charles; Arya, Dev P. Journal of Carbohydrate Chemistry, 2005 , vol. 24, # 2 p. 145 - 160 |
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~%
Thymidine,5'-am... CAS#:25152-20-9 |
| Literature: Druillennec, Sabine; Meudal, Herve; Roques, Bernard P.; Fournie-Zaluski, Marie-Claude Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 4 p. 627 - 632 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 4 | |
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| DownStream 1 | |
CAS#:13276-53-4This table lists relevant public references with title, journal and publication metadata for this compound.
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Measurement of carbamoylating activity of nitrosoureas and isocyanates by a novel high-pressure liquid chromatography assay.
Biochem. Pharmacol. 35(14) , 2359-65, (1986) A new assay for carbamoylating activity using reversed phase liquid chromatography (HPLC) is described which offers several advantages over existing assays. A comparison was made of the extent of carb... |
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Novel acyclic amide-conjugated nucleosides and their analogues.
Nucleosides Nucleotides Nucleic Acids 28 , 103-117, (2009) An effective one-step synthesis of new amide-conjugated nucleosides and their analogues, in the presence of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) as the condensin... |
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Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas and corresponding phenyl isocyanates to 5'-amino-5'-deoxythymidine: importance of carbamoylation in mouse skin carcinogenic processes.
Carcinogenesis 13(4) , 699-702, (1992) Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas (I-X: X = -OCH3, -CH3, -H, -Cl, and -COCH3) and of their corresponding phenyl isocyanates (II-X: X = -OCH3, -CH3, -H, -Cl and -COCH3) to the... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 5'-Amino-5'-deoxy-D-thymidine |
| 5'-amino-3'-hydroxythymidine |
| 5'-amino-5'-deoxy-thymidine |
| 5'-deoxy-5'-aminothymidine |
| 5'-deoxy-5'-amino-deoxythymidine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the downstream products of 5'-amino-5'-deoxythymidine? |
| A: Related downstream products(CAS) of 5'-amino-5'-deoxythymidine: 13276-53-4. |
| Q: What is the CAS number of 5'-amino-5'-deoxythymidine? |
| A: CAS number of 5'-amino-5'-deoxythymidine is 25152-20-9. |
| Q: What is the English name of 5'-amino-5'-deoxythymidine? |
| A: The English name of 5'-amino-5'-deoxythymidine is 5'-amino-5'-deoxythymidine. |
| Q: What is the InChIKey of 5'-amino-5'-deoxythymidine? |
| A: InChIKey of 5'-amino-5'-deoxythymidine is PYWLBQPICCQJFF-XLPZGREQSA-N. |
| Q: What is the molecular weight of 5'-amino-5'-deoxythymidine? |
| A: Molecular weight of 5'-amino-5'-deoxythymidine is 241.24. |
| Q: What English synonyms does 5'-amino-5'-deoxythymidine have? |
| A: English synonyms of 5'-amino-5'-deoxythymidine: 5'-Amino-5'-deoxy-D-thymidine, 5'-amino-3'-hydroxythymidine, 5'-amino-5'-deoxy-thymidine, 5'-deoxy-5'-aminothymidine, 5'-deoxy-5'-amino-deoxythymidine. |
| Q: What is the molecular formula of 5'-amino-5'-deoxythymidine? |
| A: Molecular formula of 5'-amino-5'-deoxythymidine is C10H15N3O4. |
| Q: What are the uses of 5'-amino-5'-deoxythymidine? |
| A: Main uses of 5'-amino-5'-deoxythymidine: 5′-Amino-5′-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
| Q: What is the polar surface area (PSA) of 5'-amino-5'-deoxythymidine? |
| A: Polar surface area (PSA) of 5'-amino-5'-deoxythymidine is 110.34000. |
| Q: What is the SMILES notation of 5'-amino-5'-deoxythymidine? |
| A: SMILES notation of 5'-amino-5'-deoxythymidine is Cc1cn(C2CC(O)C(CN)O2)c(=O)[nH]c1=O. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Dayang Chem (Hangzhou) Co., Ltd. |