PROTAC ERα Degrader-4

Modify Date: 2024-01-29 14:32:06

PROTAC ERα Degrader-4 structure	Common Name	PROTAC ERα Degrader-4
	CAS Number	2521299-80-7	Molecular Weight	1074.23
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₅H₆₂F₃N₅O₁₀S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PROTAC ERα Degrader-4

PROTAC ERα Degrader-4 is a highly potent and selectivePROTAC ERα degrader (Ki: 5.08 μM). PROTAC ERα Degrader-4 contains OBHSAs, linker and E3 ligase ligands. PROTAC ERα Degrader-4 shows excellent cell inhibitory and ERα degradation activity against Tamoxifen-sensitive and -resistant ER+ breast cancer (BC) cells and ERα-mutated BC cells. PROTAC ERα Degrader-4 can induce apoptosis and can be used for cancer research.

Name	PROTAC ERα Degrader-4

Description	PROTAC ERα Degrader-4 is a highly potent and selectivePROTAC ERα degrader (Ki: 5.08 μM). PROTAC ERα Degrader-4 contains OBHSAs, linker and E3 ligase ligands. PROTAC ERα Degrader-4 shows excellent cell inhibitory and ERα degradation activity against Tamoxifen-sensitive and -resistant ER+ breast cancer (BC) cells and ERα-mutated BC cells. PROTAC ERα Degrader-4 can induce apoptosis and can be used for cancer research.
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC
Target	ERα:5.08 μM (Ki) ERβ:26.20 μM (Ki)
References	[1]. Xie B, et.al. Discovery of a Novel Class of PROTACs as Potent and Selective Estrogen Receptor α Degraders to Overcome Endocrine-Resistant Breast Cancer In Vitro and In Vivo. J Med Chem. 2023 May 25;66(10):6631-6651.

Molecular Formula	C₅₅H₆₂F₃N₅O₁₀S₂
Molecular Weight	1074.23

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PROTAC ERα Degrader-4

Use of PROTAC ERα Degrader-4

Names

PROTAC ERα Degrader-4 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.