Acolbifene hydrochloride
Modify Date: 2025-08-25 13:05:34
Acolbifene hydrochloride structure
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Common Name | Acolbifene hydrochloride | ||
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| CAS Number | 252555-01-4 | Molecular Weight | 494.02200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H32ClNO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Acolbifene hydrochlorideAcolbifene (EM-652) hydrochloride, the active metabolite of EM800, is an orally active pure antiestrogen and selective estrogen receptor antagonist with an IC50 of of 0.110 nM in T-47D cells. Acolbifene (EM-652) hydrochloride possesses potent and pure anticarcinogenic properties[1][2]. |
| Name | (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-ol,hydrochloride |
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| Synonym | More Synonyms |
| Description | Acolbifene (EM-652) hydrochloride, the active metabolite of EM800, is an orally active pure antiestrogen and selective estrogen receptor antagonist with an IC50 of of 0.110 nM in T-47D cells. Acolbifene (EM-652) hydrochloride possesses potent and pure anticarcinogenic properties[1][2]. |
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| Related Catalog | |
| Target |
Estrogen receptor:0.110 nM (IC50, in T-47D cells.) |
| In Vitro | Acolbifene (ACOL) does not affect pathways of cholesterol synthesis, supporting the involvement of the clearance-related receptors in its hypocholesterolemic action[2]. Acolbifene (EM-652) shows no agonistic activity on ERα and ERβ transcriptional function and blocks the estradiol (E2)-mediated activation of both ERα and ERβ[3]. Acolbifene (EM-652) shows the most potent inhibition of estradiol-stimulated cell proliferation in human breast cancer cells (ZR-75-1, MCF-7, T-47D) and is devoid of any intrinsic estrogenic activity[4]. |
| In Vivo | Acolbifene (ACOL) reduces food intake and strongly decreases cholesterolemia in rats fed a cholesterol-free diet[2]. Acolbifene (ACOL) reduces food intake (16%) and weight gain (45%, mainly fat) similarly in both dietary cohorts[2]. Animal Model: Female Sprague-Dawley rats (n = 42) initially weighing 175-200 g[2]. Dosage: 2.5 mg/kg. Administration: Oral gavage, once daily for 21 d. Result: Prevents tumor growth in rats. |
| References |
| Molecular Formula | C29H32ClNO4 |
|---|---|
| Molecular Weight | 494.02200 |
| Exact Mass | 493.20200 |
| PSA | 62.16000 |
| LogP | 6.76680 |
| Vapour Pressure | 1.42E-17mmHg at 25°C |
| UNII-KXC7811DBY |
| Acolbifene hydrochloride (USAN) |
| Acolbifene Hydrochloride |
| EM 652.Hydrochloride |
| Acolbifene HCl |