trazodone hydrochloride
Modify Date: 2025-08-21 13:21:23
trazodone hydrochloride structure
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Common Name | trazodone hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 25332-39-2 | Molecular Weight | 408.325 | |
| Density | N/A | Boiling Point | 528.5ºC at 760 mmHg | |
| Molecular Formula | C19H23Cl2N5O | Melting Point | 223ºC | |
| MSDS | USA | Flash Point | 273.4ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
Use of trazodone hydrochlorideTrazodone HCl is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.Target: 5-HT ReceptorTrazodone is a triazolopyridine derivative, chemically and pharmacologically unrelated to other currently available antidepressants. Trazodone has been successfully used in a small number of patients with depression and pre-existing cardiovascular disease. trazodone has also been used as a hypnotic for psychotropic-induced or other insomnias with some success [1]. Trazodone is an effective hypnotic for patients with antidepressant-associated insomnia [2]. Trazodone may be helpful in men with erectile dysfunction (ED), possibly more so at higher doses, and in men with psychogenic ED. Future high-quality trials should compare trazodone with placebo and other therapies in men with depression and psychogenic ED [3]. |
| Name | trazodone hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Trazodone HCl is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.Target: 5-HT ReceptorTrazodone is a triazolopyridine derivative, chemically and pharmacologically unrelated to other currently available antidepressants. Trazodone has been successfully used in a small number of patients with depression and pre-existing cardiovascular disease. trazodone has also been used as a hypnotic for psychotropic-induced or other insomnias with some success [1]. Trazodone is an effective hypnotic for patients with antidepressant-associated insomnia [2]. Trazodone may be helpful in men with erectile dysfunction (ED), possibly more so at higher doses, and in men with psychogenic ED. Future high-quality trials should compare trazodone with placebo and other therapies in men with depression and psychogenic ED [3]. |
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| Related Catalog | |
| References |
| Boiling Point | 528.5ºC at 760 mmHg |
|---|---|
| Melting Point | 223ºC |
| Molecular Formula | C19H23Cl2N5O |
| Molecular Weight | 408.325 |
| Flash Point | 273.4ºC |
| Exact Mass | 407.127960 |
| PSA | 45.78000 |
| LogP | 3.16660 |
| Appearance of Characters | powder | off-white |
| Vapour Pressure | 2.94E-11mmHg at 25°C |
| Storage condition | -20°C Freezer |
| Water Solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 23.3 mg/mL |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22;R40 |
| Safety Phrases | S22-S36 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | XZ5660000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2933990090 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |
CAS#:19794-93-5| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Case records of the Massachusetts General Hospital. Case 4-2015. A 49-year-old man with obtundation followed by agitation and acidosis.
N. Engl. J. Med. 372(5) , 465-73, (2015) A 49-year-old man was admitted to this hospital after being found unresponsive outdoors; he was next to a half-filled bottle of cloudy liquid with pill fragments. An electrocardiogram showed a QTc int... |
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Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.
Brain 138 , 3221-37, (2015) Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is... |
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Spectroscopic and calorimetric studies on trazodone hydrochloride-phosphatidylcholine liposome interactions in the presence and absence of cholesterol.
Biochim. Biophys. Acta 1838(10) , 2369-79, (2014) The interaction of antidepressant drug trazodone hydrochloride (TRZ) with dipalmitoyl phosphatidylcholine (DPPC) multilamellar liposomes (MLVs) in the presence and absence of cholesterol (CHO) was inv... |
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