L-778123 (hydrochloride)

Modify Date: 2024-01-08 09:25:17

L-778123 (hydrochloride) structure	Common Name	L-778123 (hydrochloride)
	CAS Number	253863-00-2	Molecular Weight	442.341
	Density	N/A	Boiling Point	698.9ºC at 760 mmHg
	Molecular Formula	C₂₂H₂₁Cl₂N₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	376.5ºC

Use of L-778123 (hydrochloride)

L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.IC50 value: 2 nM [1]Target: FPTasein vitro: L-778123 can completely inhibit Ki-Ras prenylation. [1] L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent. [2]in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylatedRap1A in PBMCs. [1]

Name	4-[[5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile,hydrochloride
Synonym	More Synonyms

Description	L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.IC50 value: 2 nM [1]Target: FPTasein vitro: L-778123 can completely inhibit Ki-Ras prenylation. [1] L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent. [2]in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylatedRap1A in PBMCs. [1]
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase Research Areas >> Cancer
References	[1]. Lobell RB, et al. Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. Mol Cancer Ther. 2002 Jul;1(9):747-758. [2]. Ghasemi S, et al. Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines. Adv Pharm Bull. 2013;3(1):73-77.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase

Research Areas >> Cancer

References

[1]. Lobell RB, et al. Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. Mol Cancer Ther. 2002 Jul;1(9):747-758.

[2]. Ghasemi S, et al. Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines. Adv Pharm Bull. 2013;3(1):73-77.

Boiling Point	698.9ºC at 760 mmHg
Molecular Formula	C₂₂H₂₁Cl₂N₅O
Molecular Weight	442.341
Flash Point	376.5ºC
Exact Mass	441.112305
PSA	65.16000
LogP	4.11018
Vapour Pressure	2.22E-19mmHg at 25°C
Storage condition	2-8℃

Benzonitrile, 4-[[5-[[4-(3-chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]-, hydrochloride (1:1)

4-((5-((4-(3-Chlorophenyl)-3-oxo-1-piperazinyl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride

4-[(5-{[4-(3-Chlorophenyl)-3-oxo-1-piperazinyl]methyl}-1H-imidazol-1-yl)methyl]benzonitrile hydrochloride (1:1)

Benzonitrile,4-((5-((4-(3-chlorophenyl)-3-oxo-1-piperazinyl)methyl)-1H-imidazol-1-yl)methyl)-,monohydrochloride

4-[(5-{[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl}-1h-imidazol-1-yl)methyl]benzonitrile hydrochloride(1:1)

L 778123

L-778123

L-778123 HCl

L-778123 (hydrochloride)

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: L-778123(hydrochloride)
Price: Negotiable
Purity: 99.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: L-778123 HCl
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: L-778123 HCl
Price: $550.0/100mg $1000.0/250mg $1900.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: $77/10mM*1mLinDMSO

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L-778123 (hydrochloride)

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