17beta(h),21beta(h)-hop-22(29)-en-3-one

Modify Date: 2024-01-05 18:19:14

17beta(h),21beta(h)-hop-22(29)-en-3-one Structure
17beta(h),21beta(h)-hop-22(29)-en-3-one structure
Common Name 17beta(h),21beta(h)-hop-22(29)-en-3-one
CAS Number 25615-11-6 Molecular Weight 424.70200
Density N/A Boiling Point N/A
Molecular Formula C30H48O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 17beta(h),21beta(h)-hop-22(29)-en-3-one


3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory[1].

 Names

Name 17beta(h),21beta(h)-hop-22(29)-en-3-one
Synonym More Synonyms

 17beta(h),21beta(h)-hop-22(29)-en-3-one Biological Activity

Description 3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory[1].
Related Catalog
In Vitro 3-Oxo-hop-22(29)-ene (compound 2) (50 μM; 24 hours) reduces the viability of T. cruzi by more than 20%, and has a moderate effecton on T. rangeli and L. mexicana[1]. 3-Oxo-hop-22(29)-ene (10, 100 μM; 48 hours) causes 1.51% and 7.39% inhibition activity to yeast α-glucosidase respectively[1]. Cell Viability Assay[1] Cell Line: Saccharomyces cerevisiae (type 1) and mammalian yeast (type 2) α-glucosidases, T. cruzi, T. rangeli, L. mexicana Concentration: 10 μM, 50 μM, 100 μM Incubation Time: 24 hours, 48 hours Result: Reduced the viability of T. cruzi by more than 20%, and had a moderate effecton on T. rangeli and L. mexicana Inhibited Yeast α-glucosidase.
In Vivo 3-Oxo-hop-22(29)-ene (0.31 μmol/ear; application; once) decreases 17.50 % the inflammation of mouse ear edema model[1]. Animal Model: Adult male CD-1 mice (25-30 g) (Mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA))[1] Dosage: 0.31 μmol/ear Administration: Apply to both faces of the right ear; once Result: Decreased 17.50% the inflammation of mouse ear edema model.
References

[1]. López-Huerta FA, et al. Hopane-type triterpenes from Cnidoscolus spinosus and their bioactivities. Bioorg Chem. 2020 Jul;100:103919.

 Chemical & Physical Properties

Molecular Formula C30H48O
Molecular Weight 424.70200
Exact Mass 424.37100
PSA 17.07000
LogP 8.23300

 Synthetic Route

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17beta(h),21beta(h)-hop-22(29)-en-3-one Structure

17beta(h),21bet...

CAS#:25615-11-6

Literature: Murakami,T.; Chen,C.-M. Chemical and Pharmaceutical Bulletin, 1971 , vol. 19, p. 25 - 30

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17beta(h),21beta(h)-hop-22(29)-en-3-one Structure

17beta(h),21bet...

CAS#:25615-11-6

Literature: Aimi, Norio; Kawada, Kazuhiro; Sakai, Shin-ichiro Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 10 p. 3765 - 3768

 Precursor & DownStream

Precursor  1

DownStream  1

 Synonyms

androsteronehemisuccinate
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