(1S,2S)-ML-SI3

Modify Date: 2024-01-19 16:32:49

(1S,2S)-ML-SI3 structure	Common Name	(1S,2S)-ML-SI3
	CAS Number	2563870-87-9	Molecular Weight	429.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₃₁N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (1S,2S)-ML-SI3

(1S,2S)-ML-SI3 is the trans-isomer of ML-SI3, a TRPML inhibitor. The (-)-isomer is a potent inhibitor of TRPML1 and TRPML2 (IC50=1.6 μM/2.3 μM) and a weak inhibitor of TRPML3 (IC50=12.5 μM), whereas the (+)-enantiomer is an inhibitor on TRPML1 (IC50=5.9 μM), but an activator on TRPML 2 and 3[1].

Name	(1S,2S)-ML-SI3

Description	(1S,2S)-ML-SI3 is the trans-isomer of ML-SI3, a TRPML inhibitor. The (-)-isomer is a potent inhibitor of TRPML1 and TRPML2 (IC50=1.6 μM/2.3 μM) and a weak inhibitor of TRPML3 (IC50=12.5 μM), whereas the (+)-enantiomer is an inhibitor on TRPML1 (IC50=5.9 μM), but an activator on TRPML 2 and 3[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer
Target	IC50: 1.6 μM (TRPML1), 2.3 μM (TRPML2), 12.5 (TRPML3) for the (-)-isome of (1S,2S)-ML-SI3; 5.9 μM (TRPML1) for the (+)-enantiomer[1]
References	[1]. Leser C, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.

Molecular Formula	C₂₃H₃₁N₃O₃S
Molecular Weight	429.58

(1S,2S)-ML-SI3

Use of (1S,2S)-ML-SI3

Names

(1S,2S)-ML-SI3 Biological Activity

Chemical & Physical Properties