(1S,2S)-ML-SI3

• 常用名: (1S,2S)-ML-SI3
• 英文名: (1S,2S)-ML-SI3
• CAS号: 2563870-87-9
• 分子量: 429.58
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₃₁N₃O₃S
• 熔点: N/A
• 闪点: N/A

(1S,2S)-ML-SI3用途

(1S,2S)-ML-SI3是TRPML抑制剂ML-SI3的反式异构体。(-)-异构体是TRPML1和TRPML2的强效抑制剂(IC50=1.6μM/2.3μM),也是TRPML3的弱抑制剂(IC50/12.5μM)；而(+)-对映体是TRPMO1的抑制剂(IC50:5.9μM)但是TRPML2和3的激活剂[1]。

(1S,2S)-ML-SI3名称

• 英文名: (1S,2S)-ML-SI3

(1S,2S)-ML-SI3生物活性

• 描述: (1S,2S)-ML-SI3是TRPML抑制剂ML-SI3的反式异构体。(-)-异构体是TRPML1和TRPML2的强效抑制剂(IC50=1.6μM/2.3μM),也是TRPML3的弱抑制剂(IC50/12.5μM)；而(+)-对映体是TRPMO1的抑制剂(IC50:5.9μM)但是TRPML2和3的激活剂[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 癌症
• 靶点实验:

  IC50: 1.6 μM (TRPML1), 2.3 μM (TRPML2), 12.5 (TRPML3) for the (-)-isome of (1S,2S)-ML-SI3; 5.9 μM (TRPML1) for the (+)-enantiomer[1]

• 参考文献:

  [1]. Leser C, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.

(1S,2S)-ML-SI3物理化学性质

• 分子式: C₂₃H₃₁N₃O₃S
• 分子量: 429.58
• InChIKey: OVTXOMMQHRIKGL-SFTDATJTSA-N
• SMILES: COc1ccccc1N1CCN(C2CCCCC2NS(=O)(=O)c2ccccc2)CC1

(1S,2S)-ML-SI3靶点实验

查看更多实验

实验名称：Inhibition of human TRPML1deltaNC-YFP expressed in HEK293 cells at 10 uM stimulated w... 来源：ChEMBL 靶标：Mucolipin-1 External Id：CHEMBL4819503

实验名称：Inhibition of human TRPML2-YFP expressed in HEK293 cells preincubated for 10 mins fol... 来源：ChEMBL 靶标：Mucolipin-2 External Id：CHEMBL4819509

实验名称：Inhibition of human TRPML2-YFP expressed in HEK293 cells at 10 uM stimulated with ML-... 来源：ChEMBL 靶标：Mucolipin-2 External Id：CHEMBL4819506

实验名称：Inhibition of human TRPML1deltaNC-YFP expressed in HEK293 cells preincubated for 10 m... 来源：ChEMBL 靶标：Mucolipin-1 External Id：CHEMBL4819507

实验名称：Activation of human TRPML2-YFP expressed in HEK293 cells incubated for 10 mins by Flu... 来源：ChEMBL 靶标：Mucolipin-2 External Id：CHEMBL4819512

实验名称：Activation of human TRPML3-YFP expressed in HEK293 cells incubated for 10 mins by Flu... 来源：ChEMBL 靶标：Mucolipin-3 External Id：CHEMBL4819513

实验名称：Inhibition of human TRPML3-YFP expressed in HEK293 cells preincubated for 10 mins fol... 来源：ChEMBL 靶标：Mucolipin-3 External Id：CHEMBL4819510

实验名称：Activation of human TRPML1deltaNC-YFP expressed in HEK293 cells incubated for 10 mins... 来源：ChEMBL 靶标：Mucolipin-1 External Id：CHEMBL4819511

实验名称：Inhibition of human TRPML3-YFP expressed in HEK293 cells at 10 uM stimulated with ML-... 来源：ChEMBL 靶标：Mucolipin-3 External Id：CHEMBL4819514

实验名称：Inhibition of human TRPML1deltaNC-YFP expressed in HEK293 cells at 10 uM stimulated w... 来源：ChEMBL 靶标：Mucolipin-1 External Id：CHEMBL4819515

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