N,2-Dimethylalanine

Modify Date: 2024-01-06 14:30:23

N,2-Dimethylalanine Structure
N,2-Dimethylalanine structure
Common Name N,2-Dimethylalanine
CAS Number 2566-34-9 Molecular Weight 117.146
Density 1.0±0.1 g/cm3 Boiling Point 192.5±23.0 °C at 760 mmHg
Molecular Formula C5H11NO2 Melting Point > 300ºC
MSDS Chinese USA Flash Point 70.2±22.6 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of N,2-Dimethylalanine


α-(Methylamino)isobutyric acid is a specific substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na+-dependent manner[1].

 Names

Name 2-methyl-2-(methylamino)propanoic acid
Synonym More Synonyms

 N,2-Dimethylalanine Biological Activity

Description α-(Methylamino)isobutyric acid is a specific substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na+-dependent manner[1].
Related Catalog
In Vitro ATA3 is a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. ATA1 (also known as GlnT) and ATA2 (also known as SAT2), have been cloned from rat and human tissues. These transporters mediate the uptake of short-chain neutral amino acids in a Na+-dependent manner[1].
References

[1]. M Sugawara, et al. Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. Biochim Biophys Acta. 2000 Dec 20;1509(1-2):7-13.

[2]. Y Kudo, et al. Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. Placenta. 2002 Aug;23(7):536-41.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 192.5±23.0 °C at 760 mmHg
Melting Point > 300ºC
Molecular Formula C5H11NO2
Molecular Weight 117.146
Flash Point 70.2±22.6 °C
Exact Mass 117.078979
PSA 49.33000
LogP -0.10
Vapour Pressure 0.2±0.8 mmHg at 25°C
Index of Refraction 1.442
Storage condition −20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36
Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2922499990

 Synthetic Route

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N,2-Dimethylalanine Structure

N,2-Dimethylalanine

CAS#:2566-34-9

Literature: Chemische Berichte, , vol. 46, p. 1355 Chemische Berichte, , vol. 47, p. 2923

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N,2-Dimethylalanine Structure

N,2-Dimethylalanine

CAS#:2566-34-9

Literature: Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 223, p. 70

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N,2-Dimethylalanine Structure

N,2-Dimethylalanine

CAS#:2566-34-9

Literature: Helvetica Chimica Acta, , vol. 17, p. 579

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Articles28

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Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).

Bioorg. Med. Chem. 19 , 6409-18, (2011)

The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitati...

Unique antitumour effects of L-2,4 diaminobutyric acid on cultured hepatoma cells.

Anticancer Res. 23 , 1245-1248, (2003)

A single hepatoma cell line was grown in vitro and incubated with L-2,4 diaminobutyric acid (DAB), a non-metabolizable amino acid, under various conditions. The tumour cells were irreversibly damaged ...

Integrin participates in the effect of thyroxine on plasma membrane in immature rat testis.

Biochim. Biophys. Acta 1830(3) , 2629-37, (2013)

The secretory activity of Sertoli cells (SC) is dependent on ion channel functions and protein synthesis and is critical to ongoing spermatogenesis. The aim of this study was to investigate the mechan...

 Synonyms

N-Methyl-a-aminoisobutyric acid
2,N-Dimethylalanine (2-(Methylamino)-2-methylpropionic acid
N,2-Dimethylalanine
2 methylaminoisobutyrate
MFCD00004191
2,N-Dimethylalanine
N,2-Dimethylalanine Hydrate
2-(MethylaMino)isobutyric Acid Hydrate
Alanine, N,2-dimethyl-
2-(Methylamino)-2-methylpropionic acid
2-Methylaminoisobutyric acid
EINECS 219-898-2
2-(Methylamino)isobutyric acid
N-Methyl-α-aminoisobutyric acid
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