KTX-612

Modify Date: 2024-04-09 10:28:43

KTX-612 Structure
KTX-612 structure
Common Name KTX-612
CAS Number 2573298-14-1 Molecular Weight 868.94
Density N/A Boiling Point N/A
Molecular Formula C46H51F3N8O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of KTX-612


KTX-612 is an orally active IRAK4 degrader with a DC50 value of 7 nM. KTX-612 can be used for the research of oncology[1].

 Names

Name KTX-612

 KTX-612 Biological Activity

Description KTX-612 is an orally active IRAK4 degrader with a DC50 value of 7 nM. KTX-612 can be used for the research of oncology[1].
Related Catalog
Target

IRAK4:7 nM (DC50)

In Vitro KTX-612 has activity for IRAK4 with a DC50 value of 7 nM[1].
In Vivo KTX-612 (oral; 10 mg/kg) impacts oral absorption[1]. Animal Model: Rat[1] Dosage: 10 mg/kg Administration: Oral Result: Rat PO PK (10 mg/kg) KTX-612 %F 1 AUC(μM*hr) 0.060
References

[1]. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.

 Chemical & Physical Properties

Molecular Formula C46H51F3N8O6
Molecular Weight 868.94
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