1,3-Cyclohexanediyldimethanamine

Modify Date: 2024-01-02 16:42:06

1,3-Cyclohexanediyldimethanamine Structure
1,3-Cyclohexanediyldimethanamine structure
Common Name 1,3-Cyclohexanediyldimethanamine
CAS Number 2579-20-6 Molecular Weight 142.242
Density 0.9±0.1 g/cm3 Boiling Point 219.9±8.0 °C at 760 mmHg
Molecular Formula C8H18N2 Melting Point -70 °C
MSDS Chinese USA Flash Point 106.1±0.0 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Names

Name [3-(aminomethyl)cyclohexyl]methanamine
Synonym More Synonyms

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 219.9±8.0 °C at 760 mmHg
Melting Point -70 °C
Molecular Formula C8H18N2
Molecular Weight 142.242
Flash Point 106.1±0.0 °C
Exact Mass 142.147003
PSA 52.04000
LogP 0.47
Vapour Pressure 0.1±0.4 mmHg at 25°C
Index of Refraction 1.478
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GU7000000
CHEMICAL NAME :
Cyclohexane, 1,3-bis(aminomethyl)-
CAS REGISTRY NUMBER :
2579-20-6
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C8-H18-N2
MOLECULAR WEIGHT :
142.28
WISWESSER LINE NOTATION :
L6TJ A1Z C1Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
880 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
HURC** Huntingdon Research Center Reports. (Box 527, Brooklandville, MD 21022) Volume(issue)/page/year: -,-,1973
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302 + H312-H314-H412
Precautionary Statements P273-P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C
Risk Phrases R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R34:Causes burns. R22:Harmful if swallowed.
Safety Phrases S26-S27-S28-S36/37/39-S45-S25
RIDADR UN 2735 8/PG 2
WGK Germany 3
RTECS GU7000000
Packaging Group I
Hazard Class 8
HS Code 2921300090

 Synthetic Route

~0%

Detail
Literature: DOW GLOBAL TECHNOLOGIES, INC. Patent: WO2007/5594 A2, 2007 ; Location in patent: Page/Page column 18-19 ;

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1,3-Cyclohexanediyldimethanamine Structure

1,3-Cyclohexane...

CAS#:2579-20-6

Literature: WO2007/5594 A2, ; Page/Page column 14-16 ;

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1,3-Cyclohexanediyldimethanamine Structure

1,3-Cyclohexane...

CAS#:2579-20-6

Literature: Journal of Medicinal Chemistry, , vol. 8, p. 401 - 404

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1,3-Cyclohexanediyldimethanamine Structure

1,3-Cyclohexane...

CAS#:2579-20-6

Literature: US2012/116099 A1, ; Page/Page column 8 ;

 Customs

HS Code 2921300090
Summary 2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles3

More Articles
Retrograde transport of protein toxins under conditions of COPI dysfunction.

Biochim. Biophys. Acta 1589(2) , 124-39, (2002)

Retrograde transport dependent on coat protein I (COPI) was impaired using two different approaches and the effects on the retrograde transport of protein toxins were investigated. One approach was to...

Use of aminoglycoside antibiotics and related compounds to study ADP-ribosylation factor (ARF)/coatomer function in Golgi traffic.

Meth. Enzymol. 329 , 372-9, (2001)

Inhibition of secretion by 1,3-Cyclohexanebis(methylamine), a dibasic compound that interferes with coatomer function.

Mol. Biol. Cell 10(4) , 921-33, (1999)

We noted previously that certain aminoglycoside antibiotics inhibit the binding of coatomer to Golgi membranes in vitro. The inhibition is mediated in part by two primary amino groups present at the 1...

 Synonyms

1,3-Di(aminomethyl)cyclohexane
L6TJ A1Z C1Z
1,3-Cyclohexanebis(methylamine)
Kodak silver halide solvent HS-103
EINECS 219-941-5
1,3-Bis(aminomethyl)cyclohexane
1,3-Cyclohexanedimethanamine
1,3-Cyclohexanediyldimethanamine
Hexahydro-m-xylylenediamine
MFCD00001522
Cyclohexane-1,3-diyldimethanamine
trans 1,3-bis-aminomethylcyclohexane