CCG258747
Modify Date: 2025-08-30 20:37:13
CCG258747 structure
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Common Name | CCG258747 | ||
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| CAS Number | 2615910-00-2 | Molecular Weight | 502.54 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H27FN4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CCG258747CCG258747 is a selective GRK2 inhibitor (IC50=18 nM) with high selectivity over GRK1, GRK5, PKA, and ROCK1 (518, 83, >5500, and >550–fold, respectively).CCG258747 also blocks the internalization of the µ-opioid receptor. G protein-coupled receptor (GPCR) kinases (GRKs) are attractive targets for the research of heart failure[1]. |
| Name | CCG258747 |
|---|
| Description | CCG258747 is a selective GRK2 inhibitor (IC50=18 nM) with high selectivity over GRK1, GRK5, PKA, and ROCK1 (518, 83, >5500, and >550–fold, respectively).CCG258747 also blocks the internalization of the µ-opioid receptor. G protein-coupled receptor (GPCR) kinases (GRKs) are attractive targets for the research of heart failure[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C28H27FN4O4 |
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| Molecular Weight | 502.54 |
| InChIKey | KGSBEYKVWODBRD-ICSRJNTNSA-N |
| SMILES | O=C(NCc1[nH]nc2ccccc12)c1cc(C2CCNCC2COc2ccc3c(c2)OCO3)ccc1F |