MK-0159
Modify Date: 2024-09-21 19:28:23
MK-0159 structure
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Common Name | MK-0159 | ||
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| CAS Number | 2641484-61-7 | Molecular Weight | 400.49 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H24N4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MK-0159MK-0159 (compound 37) is an orally active, potent and selective CD38 inhibitor, with IC50 values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart[1]. |
| Name | MK-0159 |
|---|
| Description | MK-0159 (compound 37) is an orally active, potent and selective CD38 inhibitor, with IC50 values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart[1]. |
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| Related Catalog | |
| Target |
IC50: 3 nM (mouse CD38), 22 ± 5 nM (hCD38), 70 nM (rat CD38)[1] |
| References |
| Molecular Formula | C20H24N4O3S |
|---|---|
| Molecular Weight | 400.49 |