FD274
Modify Date: 2024-01-06 13:45:50
FD274 structure
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Common Name | FD274 | ||
|---|---|---|---|---|
| CAS Number | 2641899-38-7 | Molecular Weight | 480.90 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H14ClFN6O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FD274FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research[1]. |
| Name | FD274 |
|---|
| Description | FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research[1]. |
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| Related Catalog | |
| Target |
PI3Kα:0.65 nM (IC50) PI3Kβ:1.57 nM (IC50) PI3Kδ:0.65 nM (IC50) PI3Kγ:0.42 nM (IC50) mTOR:2.03 nM (IC50) |
| References |
| Molecular Formula | C22H14ClFN6O2S |
|---|---|
| Molecular Weight | 480.90 |